Esobest MUPS 20 mg (MUPS Tablet)
Unit Price: ৳ 10.00 (6 x 10: ৳ 600.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Esomeprazole mups preparation |
| Company | Sharif pharmaceuticals ltd |
| Also available as |
Indications
- Gastro-esophageal Reflux Disease (GERD)
- Risk reduction in NSAID associated gastric ulcer
- H. pylori eradication (Triple therapy)
- Zollinger-Ellison syndrome and idiopathic hypersecretion
Composition
- 133.333 mg (15%w/w) of Esomeprazole enteric coated pellets equivalent to 20 mg Esomeprazole (as Esomeprazole Magnesium Trihydrate USP)
- 266.67 mg (15% w/w) of Esomeprazole enteric coated pellets equivalent to 40 mg Esomeprazole (as Esomeprazole Magnesium Trihydrate USP)
Description
- Abbreviation for Multiple-Unit Pellet System (MUPS)
- Combines advantages of tablets and pellet-filled capsules
- Ensures greater bioavailability
- Ensures uniform emptying of micro pellets into small intestine
- Combines fast acting and sustained action
- Ensures uniform drug release
- Once daily dosing
- Ensures better and more uniform drug absorption
- Minimizes fluctuation in plasma concentration of drug
Pharmacology
- Inhibits gastric acid by blocking the hydrogen-potassium adenosine triphosphatase enzyme system
Dosage
- Erosive esophagitis - adult (≥18 years): 40 mg once daily for 4 weeks
- Maintenance of healing of erosive esophagitis - adult (≥18 years): 20 mg once daily
- H. pylori eradication - adult (≥18 years): 20 mg twice daily for 7 days
- Zollinger-Ellison syndrome and idiopathic hypersecretion - adult (≥18 years): 40-80 mg twice daily
- Children 1-11 years: 10 mg or 20 mg once daily for 8 weeks
Administration
- Tablets should be swallowed whole with liquid
- If required, the tablets can be dispersed in half a glass of non-carbonated water
- Pellets must not be chewed or crushed
Interaction
- Extensively metabolized in the liver by CYP2C19 and CYP3A4
- No clinically significant interactions with phenytoin, warfarin, quinidine, clarithromycin or amoxicillin
Contraindications
- Contraindicated in patient with known hypersensitivity to any of the formulation
Side Effects
- Headache
- Diarrhea
- Nausea
- Flatulence
- Abdominal pain
- Constipation
- Dry mouth
Pregnancy & Lactation
- Manufacturer advises caution
- Not known if Esomeprazole or its metabolites appear in human breast milk
Precautions & Warnings
- Use carefully if the patient has severe liver dysfunction and severe renal impairment
- May slightly increase the risk of hip, wrist and spine fracture
Storage Conditions
- Store in a cool & dry place below 25ºC
- Protect from light
- Keep out of reach of children
Chemical Structure
- Molecular Formula : C17H19N3O3S
Common Questions about Esobest MUPS 20 mg Tablet
- PPIs work by reducing the amount of acid produced in the stomach
- Used to treat gastroesophageal reflux disease (GERD), ulcers, and conditions involving excess stomach acid
- Relieves heartburn and GERD symptoms
- Aids in healing erosive esophagitis