Esobest MUPS 40 mg (MUPS Tablet)

Unit Price: ৳ 14.00 (3 x 10: ৳ 420.00)
Strip Price: ৳ 140.00

Medicine Details

Category Details
Generic Esomeprazole mups preparation
Company Sharif pharmaceuticals ltd
Also available as
Esobest mups 20 mg tablet

Indications

  • Gastro-esophageal Reflux Disease (GERD)
  • Risk reduction in NSAID associated gastric ulcer
  • H. pylori eradication (Triple therapy)
  • Zollinger-Ellison syndrome and idiopathic hypersecretion

Composition

  • Esomeprazole MUPS 20 Tablet: 20 mg Esomeprazole (as Esomeprazole Magnesium Trihydrate USP)
  • Esomeprazole MUPS 40 Tablet: 40 mg Esomeprazole (as Esomeprazole Magnesium Trihydrate USP)

Description

  • MUPS is abbreviation for Multiple-Unit Pellet System
  • Ensures greater bioavailability
  • Ensures uniform emptying of micro pellets from stomach into small intestine facilitates rapid dissolution of enteric coating and drug release resulting in early Tmax and Cmax
  • Ensures lesser possibility of dose dumping
  • Combination of fast acting and sustained action
  • Ensures uniform drug release
  • Once daily dosing
  • Ensures better and more uniform drug absorption
  • Is better than capsules in reducing the esophageal residence time
  • Minimizes fluctuation in plasma concentration of drug

Pharmacology

Inhibits gastric acid by blocking the hydrogen-potassium adenosine triphosphatase enzyme system (the proton pump) of the gastric parietal cell

Dosage

  • 40 mg once daily for 4 weeks (Adult)
  • 20 mg once daily for maintenance of healing of erosive esophagitis (Adult)
  • 20 mg twice daily for 7 days for H. pylori eradication (Adult)
  • 40-80 mg twice daily for Zollinger-Ellison syndrome and idiopathic hypersecretion (Adult)
  • 10-20 mg once daily for children 1-11 years

Administration

Tablets should be swallowed whole with liquid; can also be dispersed in half a glass of non-carbonated water

Interaction

  • Not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1 and 3A4
  • No clinically relevant interactions with drugs metabolized by these CYP enzymes expected
  • Potentially interferes with CYP2C19
  • May interfere with the absorption of drugs where gastric pH is important determinant of bioavailability

Contraindications

Contraindicated in patient with known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

Manufacturer advises caution; not known if Esomeprazole or its metabolites appear in human breast milk

Precautions & Warnings

  • Use carefully if the patient has severe liver dysfunction and severe renal impairment
  • May slightly increase the risk of hip, wrist and spine fracture over a period of more than one year

Storage Conditions

Store in a cool & dry place below 25°C, protect from light; keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S

Common Questions about Esobest MUPS 40 mg Tablet

  • PPIs work by reducing the amount of acid produced in the stomach
  • Used to treat gastroesophageal reflux disease (GERD), ulcers, and other conditions that involve too much stomach acid
  • Aids in healing erosive esophagitis and prevents its recurrence
  • Side effects may include headaches, diarrhea, nausea, gas, stomach pain, constipation, and dry mouth
  • Caution advised during pregnancy and breastfeeding

Related Brands