Exiron 100 mg/5 ml (IV Injection or Infusion)

5 ml ampoule: ৳ 330.00

Medicine Details

Category Details
Generic Iron sucrose
Company Sharif pharmaceuticals ltd

Indications

  • Rapid iron supply for deficiency
  • Treatment for patients unable to tolerate oral iron therapy
  • Treatment for patients with active inflammatory bowel disease
  • Anemia in chronic kidney disease patients receiving erythropoietin
  • Anemia in chronic kidney disease patients not receiving erythropoietin
  • Anemia in hemodialysis dependent-chronic kidney disease patients receiving erythropoietin
  • Anemia in peritoneal dialysis dependent-chronic kidney disease patients receiving erythropoietin
  • Treatment of iron deficiency anemia in surgical patients
  • Treatment of iron deficiency anemia in blood donors
  • Treatment of iron deficiency anemia in postpartum patients

Pharmacology

  • Therapeutic class: Haematinic
  • Composition: Polynuclear Iron (III) Hydroxide in Sucrose
  • Sucrose concentration: Approximately 30% w/v (300 mg/ml)
  • pH range: 10.5-11.1
  • Administration: Intravenous use
  • Dissociation and transfer of iron and sucrose by reticuloendothelial system
  • Iron distribution in liver, spleen, and bone marrow
  • Ferritin binding and sequestering of iron
  • Transferrin synthesis and distribution
  • Elimination half-life: 6 hours
  • Total clearance: 1.2 L/h
  • Volume distribution: 10.0 L (non-steady state), 7.9 L (steady state)

Dosage

  • Adults and Elderly: 5-10 ml Iron Sucrose Injection (100-200 mg Iron) once to three times a week
  • Children: Limited data available; dosage based on clinical need and haemoglobin level

Administration

  • Intravenous injection: Can be administered undiluted at recommended rate or as a test dose
  • Infusion: Preferably administered by drip infusion in diluted solutions to reduce risk of hypotensive episodes

Interaction

Not studied; should not be administered concomitantly with oral iron preparations

Contraindications

  • Evidence of iron overload
  • Known hypersensitivity to iron sucrose or inactive components
  • Anaemia not caused by iron deficiency
  • History of allergic disorders, liver disease, and infections

Side Effects

  • Hypotension
  • Leg cramps
  • Nausea
  • Headache
  • Vomiting
  • Diarrhea
  • Fever
  • Chest pain
  • Abdominal pain
  • Dizziness
  • Hypersensitivity reactions
  • Pruritus
  • Application site reaction

Pregnancy & Lactation

Category-B; caution during pregnancy and lactation due to limited studies

Precautions & Warnings

  • Monitoring of hematologic and haematinic parameters required
  • Caution in presence of tissue iron overload
  • Serious hypersensitivity reactions reported rarely
  • Caution in administering to patients with hypotension

Use in Special Populations

  • Pediatric use not established
  • No significant differences observed in geriatric use

Overdose Effects

  • Accumulation of iron in storage sites leading to hemosiderosis
  • Symptoms: hypotension, headache, vomiting, nausea, dizziness, edema, cardiovascular collapse
  • Monitoring of iron parameters for recognition of accumulation
  • Avoiding iron overload by discontinuing when serum ferritin levels exceed guidelines

Therapeutic Class

Parenteral Iron Preparations

Storage Conditions

Cool and dry place (15°C-30°C), protected from light; do not freeze

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