R-Penem 500 mg/vial (IV Injection or Infusion)

500 mg vial: ৳ 700.00

Medicine Details

Category Details
Generic Meropenem trihydrate
Company Jenphar bangladesh ltd
Also available as
R penem 1 gm injection

Indications

  • Pneumonia and Nosocomial Pneumonia
  • Urinary Tract Infections
  • Intra-abdominal Infections
  • Gynaecological Infections
  • Skin and Skin Structure Infections
  • Meningitis
  • Septicaemia
  • Pulmonary infections in cystic fibrosis
  • Empiric treatment for presumed infections in patients with febrile neutropenia

Pharmacology

Bactericidal action by interfering with bacterial cell wall synthesis, potent activity against a broad spectrum of bacteria

Dosage

  • Adults:
    • 500 mg to 1 gm every 8 hours
    • 1 g IV every 8 hours for specific infections
  • Children:
    • 10 to 40 mg/kg intravenously every 8 hours
    • Dosage varies based on type and severity of infection

Administration

Intravenous infusion over approximately 15-30 minutes

Interaction

  • Probenecid interaction inhibits renal excretion
  • May reduce serum valproic acid levels

Contraindications

Hypersensitivity to the product

Side Effects

  • Inflammation
  • Thrombophlebitis
  • Pain at injection site
  • Skin reactions
  • Abdominal pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Headache

Pregnancy & Lactation

Pregnancy Category B, cautious usage during lactation

Precautions & Warnings

  • Discontinue if allergic reaction occurs
  • Use with caution in hepatic disease patients

Use in Special Populations

  • Dosage adjustments for renal impairment
  • No adjustments for hepatic impairment
  • No adjustments for elderly unless creatinine clearance is low
  • Efficacy and tolerability not established in infants under 3 months

Overdose Effects

Symptomatic treatment, hemodialysis for renal impairment

Therapeutic Class

Other beta-lactam Antibiotics

Reconstitution

  • Intravenous bolus Administration: Reconstitute with sterile water for injection
  • Intravenous infusion administration: Direct constitution with compatible infusion fluid, further dilution as needed

Storage Conditions

Store in a cool, dry place away from light & moisture

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