Bisoliv 5 mg (Tablet)

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Bisoprolol hemifumarate
Company One pharma ltd
Also available as
Bisoliv 25 mg tablet

Indications

  • Hypertension
  • Angina
  • Moderate to severe heart failure

Pharmacology

  • Selective ß1 blocker
  • High affinity for the ß1 receptor
  • Reduces heart rate
  • Reduces cardiac output
  • Decreases arterial hypertension
  • No effect on cholesterol fraction
  • High therapeutic reliability
  • High absorption rate
  • Small first-pass effect
  • Absolute bioavailability of 88%
  • Extensively distributed
  • Metabolized via oxidative pathways
  • Renally eliminated metabolites
  • Balanced clearance between renal elimination and hepatic metabolism
  • Elimination half-life of 10-12 hours

Dosage & Administration

  • Individualized dose for mild to moderate hypertension
  • Usual starting dose of 5 mg once daily
  • Dose titration interval of 2 weeks
  • Increasing the dose beyond 20 mg once daily produces small incremental benefit

Interaction

  • Not to be combined with other β-blocking agents
  • Monitoring needed with catecholamine-depleting drugs
  • Caution with centrally active antihypertensive agents
  • Use with care when myocardial depressants or inhibitors of A-V conduction are used concurrently
  • Combined use with calcium channel blockers may lead to severe hypotension, bradycardia, and cardiac failure

Contraindications

  • Cardiogenic shock
  • Overt heart failure
  • Second or third degree A-V block
  • Right ventricular failure secondary to pulmonary hypertension
  • Sinus bradycardia

Side Effects

  • Fatigue
  • Dizziness
  • Headache
  • Disturbances of the gut
  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Abdominal pain
  • Cold or numb extremities
  • Muscle weakness or cramps
  • Slower than normal heart
  • Breathing difficulties due to bronchospasm

Pregnancy & Lactation

  • Not teratogenic in rats at doses up to 150 mg/kg/day
  • Fetotoxic at 50 mg/kg/day and maternotoxic at 150 mg/kg/day
  • Not teratogenic in rabbits at doses up to 12.5 mg/kg/day
  • Embryolethal at 12.5 mg/kg/day
  • No studies in pregnant women
  • Should be used during pregnancy only if potential benefit justifies potential risk to the fetus
  • Small amounts detected in the milk of lactating rats
  • Unknown excretion in human milk

Precautions & Warnings

  • Use caution in adjusting the dose in patients with renal or hepatic impairment
  • Patients with severe anaphylactic reaction history may be more reactive to allergens
  • Unresponsive to usual doses of epinephrine used to treat allergic reactions

Therapeutic Class

  • Anti adrenergic agent (Beta blockers)
  • Beta-adrenoceptor blocking drugs

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

Chemical Structure

  • Molecular Formula: C<sub>18</sub>H<sub>31</sub>NO<sub>4</sub>
  • Chemical Structure available in image

Common Questions about Bisoliv 5 mg Tablet

  • Beta-blocker medication
  • Used to lower blood pressure
  • Used to reduce the workload on the heart
  • Used to prevent chest pain
  • Should be taken by mouth
  • Should be taken once daily
  • Generally safe to take
  • Should be taken after food in a prescribed dosage
  • Should be kept in a cool dry place and in its original packaging
  • Medication may cause dizziness
  • Can hide symptoms of low blood sugar if the user is diabetic
  • Should not be stopped suddenly

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