Dopegyt 250 mg (Tablet)
Unit Price: ৳ 3.09 (10 x 10: ৳ 309.00)
Strip Price: ৳ 30.90
Medicine Details
| Category | Details |
|---|---|
| Generic | Methyldopa |
| Company | Ambee pharmaceuticals ltd |
Indications
- Hypertension
Pharmacology
- Centrally acting sympatholytic agent
- Antihypertensive agent
- Prodrug
- Alpha-2 adrenergic receptor agonist
- Vasoconstrictor adrenergic signal inhibitor
Dosage & Administration
- Usual starting dosage of 250 mg two or three times a day
- Daily dosage increase or decrease
- Use in pediatric patients based on body weight
- Maximum recommended daily dosage is 3 gm
- Dosage adjustments with concomitant antihypertensives or thiazides
- Intravenous injection for hypertensive crisis
Interaction
- Potentiation of antihypertensive effect with other antihypertensive drugs
- Reduced doses of anesthetics may be required
- Patient monitoring for lithium toxicity symptoms when coadministered with lithium
- Not recommended with ferrous sulfate or ferrous gluconate
Contraindications
- Active hepatic disease
- Hypersensitivity to any component
- On therapy with monoamine oxidase (MAO) inhibitors
Side Effects
- Sedation
- Headache
- Asthenia
- Weakness
- Angina pectoris
- Congestive heart failure
- Orthostatic hypotension
- Edema
- Weight gain
- Bradycardia
- Pancreatitis
- Colitis
- Vomiting
- Diarrhea
- Nausea
- Constipation
- Dryness of mouth
- Hyperprolactinemia
- Bone marrow depression
- Leukopenia
- Hemolytic anemia
- Hepatitis
- Jaundice
- Myocarditis
- Pericarditis
- Vasculitis
- Eosinophilia
- Parkinsonism
- Nightmares
- Psychoses
- Depression
- Dizziness
- Lightheadedness
- Paresthesias
- Arthralgia
- Myalgia
- Nasal stuffiness
- Rash
- Amenorrhea
- Gynecomastia
- Lactation
- Impotence
Pregnancy & Lactation
- Pregnancy category B
- Caution advised when given to a nursing woman
Precautions & Warnings
- Caution in patients with previous liver disease or dysfunction
- Clinical edema or weight gain may be controlled by diuretic use
- Caution if edema progresses or signs of heart failure appear
- Hypertension recurrence after dialysis
- Involuntary choreoathetotic movements observed in severe bilateral cerebrovascular disease patients
- Stop therapy if involuntary movements occur
Use in Special Populations
- No well-controlled trials in pediatric patients
- Dosing information based on literature for pediatric hypertension treatment
Overdose Effects
- Acute hypotension
- Excessive sedation
- Weakness
- Bradycardia
- Dizziness
- Constipation
- Distention
- Flatus
- Diarrhea
- Nausea
- Vomiting
- Symptomatic and supportive measures should be employed
- Gastric lavage or emesis for recent ingestion
- Infusions for promoting urinary excretion
Therapeutic Class
- Centrally acting antihypertensive drugs
Storage Conditions
- Do not store above 30°C
- Keep out of the reach of children