Disys 160 mg (Tablet)
Unit Price: ৳ 18.00 (5 x 6: ৳ 540.00)
Strip Price: ৳ 108.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Valsartan |
| Company | Healthcare pharmaceuticals ltd |
| Also available as |
Indications
- Hypertension
- Reduction of hospitalizations in patients with congestive heart failure
- Reduction of death in patients with congestive heart failure post-myocardial infarction
Pharmacology
- Belongs to angiotensin receptor blockers (ARBs) drug class
- Blocks AT1 subtype of angiotensin II receptors
- Dilates blood vessels and reduces blood pressure
- No effect on pulse rate
- High affinity for AT1 receptor over AT2 receptor
Dosage
- For hypertension: 80-160 mg once daily, maximum 320 mg daily
- For heart failure: 40 mg twice daily, may be increased to 80-160 mg twice daily
- Post-Myocardial Infarction: 20 mg twice daily, increased to 160 mg daily if tolerated
Administration
- Should be taken on an empty stomach
- Absorption reduced by 40% when taken with food
- No initial dosage adjustment required for elderly patients with mild to moderate renal and hepatic insufficiency
Interaction
- No clinically significant drug interactions found
- Studied compounds include Cimetidine, Warfarin, Furosemide, Digoxin, Atenolol, Indomethacin, Hydrochlorothiazide, Amlodipine, Glibenclamide
- Not metabolized significantly, no metabolic induction or inhibition expected
- Highly protein bound, caution with potassium sparing diuretics, potassium supplements, or salt substitutes containing potassium
Contraindications
- Hypersensitivity to any component of this product
Side Effects
- Headache
- Dizziness
- Fatigue
- Abdominal pain
- Cough
- Diarrhea
- Nausea
- Hyperkalemia
- Impotency
- Reduced renal function
- Allergic reactions
- Dyspnea
- Constipation
- Back pain
- Muscle cramps
- Rash
- Anxiety
- Insomnia
- Vertigo
- Hypotension if taken with diuretics
Pregnancy & Lactation
- Not to be used in pregnancy, especially 2nd and 3rd trimesters
- Not known whether excreted in human milk, decision should be made considering importance of the drug to the mother
Precautions & Warnings
- Care in patients with mild to moderate hepatic impairment including biliary obstructive disorder
- Dosage reduction or discontinuation may be required in patients with pre-existing renal impairment
- Caution when initiating therapy in heart failure and post-myocardial infarction patients
Use in Special Populations
- Safety and effectiveness not established in pediatric patients
- No overall difference in efficacy or safety observed in geriatric patients
- Max dosage for mild to moderate hepatic impairment: 80 mg once daily, contraindicated in severe hepatic impairment
Overdose Effects
- Manifestations: hypotension and tachycardia
- Bradycardia could occur from parasympathetic (vagal) stimulation
- Treatment: supine position, intravenous infusion of normal saline if excessive hypotension
Therapeutic Class
- Angiotensin-II receptor blocker
Storage Conditions
- Store between 15-30°C
- Protect from moisture and heat