Afluzole 50 mg/5 ml (Powder for Suspension)
35 ml bottle: ৳ 78.30
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | Ambee pharmaceuticals ltd |
| Also available as |
Title
- Afluzole
Category
- Antifungal Agent
Indications
- Vaginal Candidiasis
- Oropharyngeal Candidiasis
- Oesophageal Candidiasis
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
- Kerion
- Pityriasis versicolor
- Onychomycosis
- Invasive candidal infections and cryptococcal infections (including meningitis)
- Prevention of cryptococcal meningitis
- Prevention of fungal infections in immunocompromised patients
- Systemic Candidiasis and Cryptococcal infection
- Fungal urinary tract infections
- Disseminated candidiasis
- Prophylaxis for fungal infection in neutropenic cancer patients
- Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis
Mode of Action
- Potent inhibitor of fungal cytochrome P-450 dependent enzymes
- Responsible for the synthesis of ergosterol
Dosage & Administration
- 150 mg as a single dose for Vaginal Candidiasis
- 200 mg in 1st day followed by 100 mg daily for 14 days for Oropharyngeal Candidiasis
- 200 mg in 1st day followed by 100 mg daily for 14-30 days for Oesophageal Candidiasis
- 150 mg weekly for 4-6 weeks for Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
- 50 mg daily for 20 days for Kerion
- 400 mg as a single dose for Pityriasis versicolor
- 150 mg weekly for 12 months for Onychomycosis
- Orally or by IV infusion, 400 mg on first day then 200-400 mg daily for Invasive candidal infections and cryptococcal infections (including meningitis)
Interaction
- Increased prothrombin time after warfarin administration
- Prolonged serum half-life of concomitantly administered oral sulphonylureas
- Increased plasma concentrations of fluconazole with hydrochlorothiazide
- Increased levels of phenytoin
- Interaction with combined oral contraceptives
- Slowly increased cyclosporin concentrations
- No impairment of absorption with food, cimetidine, antacids, or following total body irradiation for bone marrow transplantation
- Decreased mean plasma clearance of theophylline
Contraindications
- Known hypersensitivity to Fluconazole or related triazole compounds
Side Effects
- Nausea
- Abdominal discomfort
- Diarrhoea
- Flatulence
- Rare rash
- Rare anaphylaxis
Pregnancy & Lactation
- Adverse fetal effects seen in animals only at doses associated with maternal toxicity
- Not recommended for use in pregnancy or in women of childbearing potential unless adequate contraception is employed
- Found in human breast milk
Precautions & Warnings
- Abnormalities in hepatic, renal, hematological and other biochemical function tests observed in some patients
- Rare instances of hepatic necrosis
- Rare exfoliative cutaneous reactions
- Discontinuation in case of rash development
- Not recommended during lactation
- Unlikely to impair ability to drive or use machinery
Use in Special Populations
- Normal dose recommended for the elderly with no evidence of renal impairment
- No adjustments in single dose therapy for renal impairment
- Normal dose for patients with creatinine clearance > 40
- Dosage intervals/daily dose adjustment for patients with creatinine clearance 21-40, 10-20, or receiving regular haemodialysis
Overdose Effects
- Supportive measures and symptomatic treatment
- Gastric lavage if necessary
- Forced volume diuresis may increase elimination rate
- Haemodialysis decreases plasma levels by approximately 50%
Therapeutic Class
- Antifungal Agents
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children