Afluzole 150 mg (Capsule)
Unit Price: ৳ 22.08 (10's pack: ৳ 220.80)
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | Ambee pharmaceuticals ltd |
| Also available as |
Title
- Afluzole Antifungal Medicine
Categories
- Medicine
- Pharmaceutical
- Healthcare
Description
- Afluzole is indicated for the treatment of various fungal infections including vaginal candidiasis, oropharyngeal candidiasis, tinea infections, pityriasis versicolor, onychomycosis, invasive candidal infections, cryptococcal infections, prevention of fungal infections in immunocompromised patients, and more.
- It is a triazole antifungal agent that inhibits fungal cytochrome P-450 dependent enzymes, essential for the synthesis of ergosterol in the fungal cell membrane.
- Dosage and administration vary based on the type of infection and patient age, with specific recommendations for adults, children, elderly, and patients with renal impairment.
- There are several known drug interactions with afluzole, impacting the efficacy and dosage of other medications, such as warfarin, sulphonylureas, hydrochlorothiazide, phenytoin, rifampicin, and combined oral contraceptives.
- The medicine is contraindicated in patients with known hypersensitivity to fluconazole or related triazole compounds, and precaution is advised in patients with serious underlying diseases, as abnormalities of hepatic, renal, haematological, and other biochemical function tests have been observed during treatment.
- Common side effects include symptoms associated with the gastrointestinal tract, nausea, abdominal discomfort, diarrhea, and flatulence, while rare cases of rash and anaphylaxis have been reported.
- Use during pregnancy and lactation is not recommended due to potential fetal effects and presence in human breast milk, and caution is recommended while driving or using machinery during therapy.
Dimensions
- Standard medicine packaging size
Color Options
- N/A
Functions
- Treatment of fungal infections
- Inhibition of fungal cytochrome P-450 dependent enzymes
- Prolonging the serum half-life of concomitantly administered medications
Materials
- Active ingredient: fluconazole
Technical Specifications
- Multiple dosage options based on the type of fungal infection
- Dosage adjustments for patients with renal impairment
- Potential impact on other medications through drug interactions
Design Elements
- Standard medicine packaging
Usability Features
- Oral and intravenous administration options
- Dosage flexibility based on age and specific conditions
Indications
- Vaginal candidiasis
- Oropharyngeal candidiasis
- Tinea infections
- Pityriasis versicolor
- Onychomycosis
- Invasive candidal infections
- Cryptococcal infections
- Prevention of fungal infections in immunocompromised patients
- Fungal urinary tract infections
- Disseminated candidiasis
- Prophylaxis for fungal infection in neutropenic cancer patients
- Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis
Pharmacology
- Potent inhibitor of fungal cytochrome P-450 dependent enzymes
- Key role in the synthesis of ergosterol in the fungal cell membrane
Dosage & Administration
- Variety of dosage options based on specific infections and patient age
- Dosage adjustments for elderly and patients with renal impairment
Interaction
- Interactions with warfarin, sulphonylureas, hydrochlorothiazide, phenytoin, rifampicin, combined oral contraceptives, cyclosporin, theophylline, and food
- Potential impact on plasma concentrations and half-life of concomitantly administered medications
Contraindications
- Known hypersensitivity to fluconazole or related triazole compounds
Side Effects
- Common gastrointestinal symptoms
- Occasional rash
- Rare cases of anaphylaxis
Pregnancy & Lactation
- Adverse fetal effects in animal studies at high dose levels
- Limited use during human pregnancy
- Not recommended during lactation
Precautions & Warnings
- Abnormalities of hepatic, renal, and biochemical function tests observed in some patients
- Rare cases of severe cutaneous reactions
- Use assessment in patients exhibiting significant rise of liver enzymes
- Not recommended during lactation
Use in Special Populations
- Dosage adjustments for elderly and patients with renal impairment
Overdose Effects
- Supportive and symptomatic treatment recommended
- Potential impact of forced volume diuresis and haemodialysis on elimination rate
Therapeutic Class
- Drugs for subcutaneous and mycoses
Storage Conditions
- Dry place away from light and heat
- Keep out of reach of children