Klion 200 mg/5 ml (Oral Suspension)

60 ml bottle: ৳ 25.75

Medicine Details

Category Details
Generic Metronidazole
Company Ambee pharmaceuticals ltd
Also available as
Klion 200 mg tablet Klion 400 mg tablet

Product Title

  • Klion 200 mg/5 ml Suspension

Categories

  • Antibiotic Medication
  • Antibacterial Drug
  • Antiprotozoal Agent
  • Amoebicides
  • Anti-diarrhoeal Antiprotozoal

Description

  • Klion 200 mg/5 ml Suspension is indicated in the treatment and prevention from viral and parasitic infections. It also prevents bacterial infections such as cold, cough, flu, vaginal infections, liver infections, skin infections, joint infections, brain infections, and respiratory tract infections.

Dosage & Administration

  • 200 mg tid or 400 mg bid for 7 days
  • 800 mg in the morning and 1-2 gm at night for 2 days
  • 2 gm as a single dose for 1 days
  • Children 7-10 yrs: 100 mg tid
  • Children 3-7 yrs: 100 mg bid
  • Children 1-3 yrs: 50 mg tid
  • 800 mg tid for 5 days
  • 400 mg tid for 7 days
  • 2 gm once daily for 3 days
  • 200 mg tid for 3 days
  • 400 mg bid for 7 days
  • 400 mg tid for 7 days

Pharmacology

  • Metronidazole is a member of the imidazole class of antibacterial drug and is classified therapeutically as an antiprotozoal agent. The 5-nitro group of Metronidazole is reduced by anaerobes metabolically. Studies have demonstrated that the reduced form of this drug interacts with DNA and gives bactericidal action of Metronidazole.

Interaction

  • Disulfiram: Psychotic reactions have been reported in patients who were using Klion and disulfiram concurrently.
  • Alcohol: Alcoholic beverages and drugs containing alcohol should not be consumed during therapy and for at least one day afterwards because of the possibility of a disulfiram-like (antabuse effect) reaction (flushing, vomiting, tachycardia). Oral anticoagulant therapy (warfarin type): Potentiation of the anticoagulant effect and increased hemorrhagic risk caused by decreased hepatic catabolism. In case of co-administration, prothrombin time should be more frequently monitored and anticoagulant therapy adjusted during treatment with Klion.
  • Lithium: Plasma levels of lithium may be increased by Klion.
  • Cyclosporin: Serum cyclosporin and serum creatinine should be closely monitored when co-administration is necessary.
  • Phenytoin or phenobarbital: increased elimination of Klion resulting in reduced plasma levels.
  • 5-Fluorouracil: Reduced clearance of 5-fluorouracil resulting in increased toxicity of 5-fluorouracil.
  • Busulfan: Plasma levels of busulfan may be increased by Klion, which may lead to severe busulfan toxicity.

Contraindications

  • Metronidazole is contraindicated in patients with a history of hypersensitivity to Metronidazole or other Nitroimidazole derivatives.

Side Effects

  • Metallic taste
  • Nausea
  • Vomiting
  • Diarrhoea
  • Drowsiness
  • Rashes

Pregnancy & Lactation

  • US FDA Pregnancy Category of Metronidazole is B. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Metronidazole have been shown to be excreted in human milk. So, caution should be exercised when Metronidazole is administered to a nursing woman.

Precautions & Warnings

  • If for compelling reasons, Klion must be administered longer than the usually recommended duration, it is recommended that hematological tests, especially leucocyte count should be carried out regularly and that patients should be monitored for adverse reactions such as peripheral or central neuropathy (such as paresthesia, ataxia, dizziness, convulsive seizures).
  • Klion should be administered with caution to patients with hepatic encephalopathy.
  • Patients should be warned that Klion may darken urine.

Use in Special Populations

  • Hepatic impairment: Klion is mainly metabolised by hepatic oxidation. Substantial impairment of Klion clearance may occur in the presence of advanced hepatic insufficiency. Significant cumulation may occur in patients with hepatic encephalopathy and the resulting high plasma concentrations of Klion may contribute to the symptoms of the encephalopathy. Klion should therefore, be administered with caution to patients with hepatic encephalopathy. The daily dosage should be reduced to one third and may be administered once daily. Patients should be warned that Klion may darken urine.
  • Renal impairment: The elimination half-life of Klion remains unchanged in the presence of renal failure. The dosage of Klion therefore needs no reduction. Such patients however retain the metabolites of Klion. The clinical significance of this is not known at present. In patients undergoing haemodialysis Klion and metabolites are efficiently removed during an eight hour period of dialysis. Klion should therefore be re-administered immediately after haemodialysis. No routine adjustment in the dosage of Klion need be made in patients with renal failure undergoing intermittent peritoneal dialysis (IDP) or continuous ambulatory peritoneal dialysis (CAPD).

Overdose Effects

  • Single oral doses of Klion, up to 12 g have been reported in suicide attempts and accidental overdoses. Symptoms were limited to vomiting, ataxia and slight disorientation. There is no specific antidote for Klion overdosages. In case of suspected massive overdosages, a symptomatic and supportive treatment should be instituted.

Storage Conditions

  • Store below 30°C
  • Keep protected from light
  • Keep medicines out of the reach of children
  • Do not use later than the date of expiry.

Indications

  • The prevention of post-operative infections due to anaerobic bacteria (particularly species of bacteroides and anaerobic streptococci)
  • The treatment of septicaemia, bacteraemia, peritonitis, brain abscess, pelvic abscess, pelvic cellulitis and post-operative wound infections caused by anaerobes
  • In the treatment of urogenital trichomoniasis
  • Bacterial vaginosis (also known as non-specific vaginitis)
  • All forms of amoebiasis (intestinal, extra-intestinal disease and that of symptomless cyst passers)
  • Giardiasis
  • Acute ulcerative gingivitis
  • Anaerobically infected leg ulcers and pressure sores
  • Acute dental infections due to anaerobic organisms
  • Antibiotic associated pseudomembranus colitis

Commonly Asked Questions

  • Klion 200 mg/5 ml Suspension is an antibiotic medication that performs its action by preventing the growth of bacterias and parasites.
  • Klion 200 mg/5 ml Suspension is used for the treatment and prevention from viral and parasitic infections. It also prevents bacterial infections such as cold, cough, flu and vaginal infections. It also controls liver, skin, joints, brain and respiratory tract infections.
  • Some side effects of Klion 200 mg/5 ml Suspension which are diarrhoea, headache, weakness, painful urination, trouble sleeping, numbness, muscle weakness and mouth ulcer.
  • Klion 200 mg/5 ml Suspension takes 1 or 2 days before you see an improvement in your health conditions.
  • Klion 200 mg/5 ml Suspension should not be used if you have the following conditions such as hives, flushing, nasal congestion, dryness of the mouth, fever, etc.
  • No, taking higher than the recommended dose of Klion 200 mg/5 ml Suspension lead to increased chances of side effects such as diarrhoea, excessive production of urine, headache, nausea, pain in the upper part of the stomach, painful and difficult urination, serious eating disorder (anorexia), etc.

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