Lotas 50 mg (Tablet)
Unit Price: ৳ 5.69 (30's pack: ৳ 170.70)
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Ambee pharmaceuticals ltd |
Indications
- Treatment of hypertension
- Renal protection in type-2 diabetic patients with proteinuria
Pharmacology
- Non-peptide orally active angiotensin II receptor blocker
- Binds to AT1 receptor in various tissues
- Reduces vasoconstriction and aldosterone release
Dosage & Administration
- Usual starting and maintenance dose of 50 mg once daily
- Option to use alone or in combination with other antihypertensive agents
- Dose adjustment for patients with intravascular volume-depletion
- Lower starting dose for patients over 75 years
- Total daily dose ranges from 25 mg to 100 mg
Interaction
- Reduced levels with rifampicin and fluconazole
- Potentiation with hydrochlorothiazide
- Potential increases in serum potassium with potassium-sparing diuretics, supplements, or salt substitutes
- Attenuation by indomethacin
- Risk of renal impairment with combined use of certain drugs
Contraindications
- Pregnancy
- Hypersensitivity to any component of the product
- Concomitant use with aliskiren in patients with diabetes
Side Effects
- Mild and transient side effects
- Common side effects include dizziness, diarrhea, nasal congestion, cough, and upper respiratory infection
- Other side effects such as fatigue, oedema, abdominal pain, chest pain, nausea, headache, and pharyngitis
Pregnancy & Lactation
- Risk to the fetus during second or third trimester
- Unknown excretion in human milk
- Consideration for discontinuation of nursing or drug
Precautions & Warnings
- Reduced fetal renal function when used in later pregnancy
- Potential symptomatic hypotension in intravascularly volume-depleted patients
- Significant increase in plasma concentration in cirrhotic patients
- Changes in renal function including renal failure in renal impaired patients
Use in Special Populations
- No initial dosage adjustment in patients with mild renal impairment
- Lower starting dose for moderate to severe renal impairment or patients on dialysis
- Consideration for lower dose in patients with hepatic impairment
- Contraindication with potassium-sparing diuretics
Therapeutic Class
- Angiotensin-II receptor blocker
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children