Lap 30 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.01 (28's pack: ৳ 140.28)

Medicine Details

Category	Details
Generic	Lansoprazole
Company	Ambee pharmaceuticals ltd

Indications

Short term treatment of active duodenal ulcer
Maintenance of healed duodenal ulcers
Short term treatment of active benign gastric ulcers
Short term treatment of active erosive esophagitis
Maintenance of healing of erosive esophagitis
Pathological hypersecretory conditions including Zollinger- Ellison Syndrome
H. pylori eradication to reduce the risk of duodenal ulcer recurrence

Pharmacology

Substituted benzimidazole, known as PPI due to its property to block the final step of acid secretion by inhibiting H+/K+ ATPase enzyme system in gastric parietal cell. Both basal and stimulated acid are inhibited.

Dosage & Administration

Benign gastric ulcer: 30 mg daily in the morning for 8 weeks
Duodenal ulcer: 30 mg daily in the morning for 4 weeks; maintenance 15 mg
NSAID-associated duodenal or gastric ulcer: 15-30 mg daily for 4 weeks, followed by a further 4 weeks if not fully healed
Zollinger-Ellison syndrome (and other hypersecretory conditions): Initially 60 mg once daily adjusted according to response; daily doses of 120 mg or more is given in two divided doses
Gastroesophageal reflux disease: 30 mg daily in the morning for 4 weeks, followed by a further 4 weeks if not fully healed; maintenance 15-30 mg daily
Acid-related dyspepsia: 15-30 mg daily in the morning for 2-4 weeks

Interaction

Selective inhibitor of the cytochrome P-450 monooxygenase system; uncertain effect on hepatic clearance; possible effect on oral combined contraceptive pill; reduction in gastric acid may influence bacterial colonization of stomach and duodenum and vitamin B12 absorption

Contraindications

Known hypersensitivity to any component of the formulation

Side Effects

Severe or irreversible adverse effects: Possible induction of carcinoid tumors by profound acid suppression; rise in serum gastrin levels; rise in serum gastrin levels may accelerate the development of atrophic gastritis; long term treatment with a proton pump inhibitor in patients with Helicobacter pylori infection may accelerate the development of atrophic gastritis
Symptomatic adverse effect: Dose dependent diarrhea occurs; headache occurs in 2-3% of treated patients

Pregnancy & Lactation

Lansoprazole should be avoided in pregnancy unless there are compelling reasons

Precautions & Warnings

Gastric malignancy should be ruled out; hepatic impairment; pregnancy and lactation

Use in Special Populations

Neonates: Not recommended for use with neonates
Children: The youngest person to have received Lap in clinical trials was 13 years old
The Elderly: No increase in adverse drug reaction