Trofurit 20 mg/2 ml (IM/IV Injection)
2 ml ampoule: ৳ 3.53 (2 x 5: ৳ 35.30)
Medicine Details
| Category | Details |
|---|---|
| Generic | Furosemide |
| Company | Ambee pharmaceuticals ltd |
| Also available as |
Indications
- Fluid retention associated with chronic congestive cardiac failure
- Fluid retention associated with acute congestive cardiac failure
- Fluid retention associated with chronic renal failure
- Maintenance of fluid excretion in acute renal failure
- Fluid retention associated with nephrotic syndrome
- Fluid retention associated with liver disease
- Hypertension
- Hypertensive crisis
- Support of forced diuresis
Pharmacology
- Monosulphonyl diuretic
- Effective in low glomerular filtration rate
- Distinctive action on renal tubular function
- Peak diuresis greater than with other agents
- Prompt onset of action
- Inhibition of sodium and chloride transport
- Independence of action from acid-base balance changes
- Inhibition of electrolyte reabsorption in the thick ascending limb of the loop of Henle
- Rapid absorption from the gastrointestinal tract
- Considerable proportions bound to plasma proteins
- Rapid excretion in the urine
Dosage & Administration
- Available as Furosemide 40 mg Tablet
- Initial adult dose is 40 mg daily
- Children's dose varies by age group
- Usual initial dose for hypertension is 80 mg
- Dosage should be adjusted according to response
- Maximum daily dose should not be exceeded
- For advanced chronic renal failure, diuretic therapy may start with Furosemide
- Furosemide Syrup has a wide therapeutic range
- Furosemide Injection dosage varies by age group
Interaction
- Marked fall in blood pressure with ACE inhibitors
- Increased serum lithium levels when given concomitantly
- Increased toxic effects of nephrotoxic antibiotics
Contraindications
- Contraindicated in anuria
- Contraindicated in electrolyte deficiency
- Contraindicated in pre-comatose states associated with liver cirrhosis
- Hypersensitivity to furosemide or sulphonamides
Side Effects
- Disturbed electrolytes and water balance
- Potential for producing alkalosis
- Uric acid retention
- Potential for acute gout
- Potential to provoke hyperglycemia
- Potential to provoke glycosuria
Pregnancy & Lactation
- Pregnancy category C
- Caution in cardiogenic shock complicated by pulmonary oedema
- Monitoring of blood pressure and pulse during rapid diuresis
- Caution in patients liable to electrolyte deficiency
- Potential inhibition of lactation or passage into breast milk
Precautions & Warnings
- Increased risk of acute retention in patients with prostatic hypertrophy or impairment of micturition
- A marked fall in blood pressure may be seen with ACE inhibitors
- Increased toxic effects of nephrotoxic antibiotics
- Adverse effects may impair the ability to perform hazardous tasks
Overdose Effects
- Dependent on the extent and consequences of electrolyte and fluid loss
- E.g. hypovolaemia, dehydration, haemoconcentration, cardiac arrhythmias
- No specific antidote known
- Management may involve measures to limit further systemic absorption
Therapeutic Class
- Loop diuretics
Storage Conditions
- Protect from light
- Do not use beyond the expiry date
- Keep out of the reach of children
- Dispense only on the prescription of a registered physician