Nilicon 1 gm/vial (IV Injection)

1 gm vial: ৳ 180.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Ethical drugs limited
Also available as
Nilicon 2 gm injection Nilicon 500 mg injection Nilicon 250 mg injection Nilicon 250 mg injection Nilicon 500 mg injection Nilicon 1 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of bacteria. It interferes with bacterial cell wall synthesis and has high stability in the presence of beta lactamases. It has a relatively long plasma elimination half-life of about 6 to 9 hours and is not metabolized in the body. It is highly protein bound and excreted primarily through urine and feces.

Dosage

  • 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day) for adults
  • 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day) for infants and children
  • Duration of therapy: continue for more than 2 days after signs and symptoms of infection have disappeared

Administration

  • Preparation of Solutions for Intramuscular / Intravenous Injections:
  • For Intramuscular Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Lidocaine HCI 1% injection
  • For Intravenous Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Water for injection
  • The injection should be administered over 2-4 minutes, by Intramuscular or Intravenous injection or by tubing infusion over a period of 30 minutes at concentration between 10 mg/mL and 40 mg/mL

Interaction

No drug interactions have been reported

Contraindications

Ceftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea and vomiting
  • Cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness
  • Local phlebitis occurs rarely following intravenous administration

Pregnancy & Lactation

Safety in human pregnancy has not been established. It should not be used in pregnancy unless absolutely indicated. Caution should be exercised when administered to a lactating mother.

Precautions & Warnings

  • Anaphylactic shock may occur
  • Shadows suggesting sludge in the gallbladder have been detected in rare cases
  • Blood picture should be checked at regular intervals during prolonged treatment

Use in Special Populations

Nilicon must not be given to neonates if premature and newborn (up to 28 days of age)

Overdose Effects

There is no specific antidote. Treatment of overdosage should be symptomatic

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Vial store in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children

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