Esomium 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00

Medicine Details

Category Details
Generic Esomeprazole
Company Jenphar bangladesh ltd
Also available as
Esomium 20 mg capsule

Title and Category

  • Product Name: Esomium 40 mg Capsule
  • Category: Proton pump inhibitor (PPI)

Dimensions

  • Capsule Size: Standard pharmaceutical capsule size

Color Options

  • Color: Usually opaque with specific color indicating dosage

Function

  • Relieves chronic heartburn symptoms
  • Heals erosive esophagitis
  • Maintains healing of erosive esophagitis
  • Aids in eradicating Helicobacter pylori infection
  • Treatment of Zollinger-Ellison Syndrome
  • Alleviates symptoms of acid-related Dyspepsia
  • Heals duodenal and gastric ulcers

Materials

  • Active Ingredient: Esomeprazole magnesium
  • Enteric-coated pellet formulation
  • Other Ingredients: Depending on the pharmaceutical formulation

Technical Specifications

  • Absorption: Peak plasma levels occur at approximately 1.5 hours after oral administration
  • Distribution: Highly bound to plasma proteins with a steady-state apparent volume of distribution of approximately 16 L
  • Metabolism: Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system
  • Excretion: Plasma elimination half-life of approximately 1–1.5 hours, with less than 1% excreted unchanged in the urine
  • Bioavailability: Approximately 90% at steady state, compared to 64% after a single dose

Design Elements

  • Proton pump inhibitor mechanism to suppress gastric acid secretion
  • Single optical isomer of proton pump inhibitor (esomeprazole)

Usability Features

  • Oral Dosage Form: Capsules and Oral Suspension
  • IV Injection or IV Infusion for specified conditions

Dosage

  • Healing of Erosive Esophagitis: 20 mg or 40 mg once daily for 4-8 weeks
  • Maintenance of Healing of Erosive Esophagitis: 20 mg once daily (clinical studies did not extend 6 months)
  • Symptomatic GERD: 20 mg once daily for 4 weeks
  • Helicobacter Pylori eradication: Specific triple therapy dosage regimen
  • Zollinger-Ellison Syndrome: Ranges from 20-80 mg once daily, individualized dosage
  • Acid-related Dyspepsia: 20-40 mg once daily for 2-4 weeks
  • Duodenal Ulcer: 20 mg once daily for 2-4 weeks
  • Gastric Ulcer: 20-40 mg once daily for 4-8 weeks
  • Specific dosages for IV Injection or IV Infusion based on age and condition

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral Suspension should be taken as per specific instructions
  • Administration of IV Injection: Preparation and administration details provided

Interaction

  • Metabolized by CYP2C19 and CYP3A4, potential drug interactions
  • Inhibition of gastric acid secretion may interfere with the absorption of specific drugs
  • Co-administration studies with clarithromycin and amoxicillin

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healed erosive esophagitis
  • Eradication of Helicobacter pylori infection
  • Treatment of Zollinger-Ellison Syndrome
  • Management of acid-related Dyspepsia
  • Healing of duodenal and gastric ulcers

Contraindications

  • Contraindicated in patients with known hypersensitivity to any of the formulation

Side Effects

  • Frequently occurring adverse events such as headache, diarrhea, nausea, flatulence, abdominal pain, constipation, and dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Animal studies show no teratogenic effects
  • Excretion in milk not studied, breastfeeding should be discontinued if essential

Precautions & Warnings

  • Symptomatic response to therapy does not preclude the presence of gastric malignancy
  • Specific instructions for patients with difficulty swallowing capsules
  • Use of antacids alongside medication

Use in Special Populations

  • Safety and efficacy not established in pediatric patients
  • Limited differences observed between elderly and younger individuals
  • Dosage adjustment recommendations for hepatic insufficiency
  • No alteration of pharmacokinetics expected in renal impairment

Overdose Effects

  • Toxicity signs and possible supportive treatment
  • No specific antidote known, symptomatic management

Storage Conditions

  • Store at a temperature not exceeding 30°C in a dry place, protect from light and moisture, keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure: Image provided

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