Neoclav 250 mg+62.5 mg (Tablet)

Unit Price: ৳ 30.00 (12's pack: ৳ 360.00)

Medicine Details

Category Details
Generic Cefuroxime axetil clavulanic acid
Company Jenphar bangladesh ltd
Also available as
Neoclav 500 mg tablet

Title and Categories

  • Neoclav 250 mg Tablet
  • Medicine
  • Cephalosporin Antibiotic
  • Beta-lactamase Inhibitor

Color Options

  • White

Dosage Form

Tablet

Packaging Options

  • Blister Pack
  • Bottle

Pack Size Options

  • 10 Tablets
  • 20 Tablets
  • 30 Tablets

Age Group

  • Adults
  • Adolescents (13 years and older)
  • Pediatric Patients (3 months to 12 years)

Indications

  • Pharyngitis/Tonsillitis caused by Streptococcus pyogenes
  • Acute Bacterial Otitis Media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis
  • Lower respiratory tract infections including pneumonia caused by Streptococcus pneumoniae, Haemophilus influenzae, Klebsiella spp., Staphylococcus aureus, E. coli
  • Uncomplicated skin and skin-structure infections caused by Staphylococcus aureus or Streptococcus pyogenes
  • Uncomplicated urinary tract infections caused by E.coli or Klebsiella pneumoniae
  • Bone and Joint Infections caused by Staphylococcus aureus
  • Uncomplicated Gonorrhoea caused by Neisseria gonorrhoeae
  • Early Lyme Disease caused by Borrelia burgdorferi
  • Septicemia caused by Staphylococcus aureus, Streptococcus pneumoniae, E.coli, Haemophilus influenzae & Klebsiella spp.
  • Meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis & Staphylococcus aureus

Pharmacology

Bactericidal second generation cephalosporin antibiotic active against a wide range of Gram-positive and Gram-negative susceptible organisms

Mechanism of Action

Interferes with bacterial cell wall synthesis by interfering with the transpeptidation process

Dosage and Administration

  • Adolescents and Adults (13 years and older):
    • Pharyngitis/tonsillitis: 250 mg b.i.d. for 5-10 days
    • Acute bacterial maxillary sinusitis: 250 mg b.i.d. for 10 days
    • Acute bacterial exacerbation of chronic bronchitis: 250-500 mg b.i.d. for 10 days
    • Secondary bacterial infections of acute bronchitis: 250-500 mg b.i.d. for 5-10 days
    • Uncomplicated skin and skin structure infections: 250-500 mg b.i.d. for 10 days
    • Uncomplicated urinary tract infections: 250 mg b.i.d. for 7-10 days
    • Uncomplicated Gonorrhoea: 1000 mg b.i.d. single dose
    • Community acquired pneumonia: 250-500 mg b.i.d. for 5-10 days
    • MDR Typhoid Fever: 500 mg b.i.d. for 10-14 days
    • Early Lyme disease: 500 mg b.i.d. for 20 days
  • Pediatric Patients (3 months to 12 years):
    • Pharyngitis/Tonsillitis: 20 mg/kg/day b.i.d for 5-10 days
    • Acute otitis media: 30 mg/kg/day b.i.d for 10 days
    • Acute bacterial maxillary sinusitis: 30 mg/kg/day b.i.d for 10 days
    • Impetigo: 30 mg/kg/day b.i.d for 10 days
  • Administration: May be taken without regard to food

Interaction

Concomitant administration of probenecid with Cefuroxime-Clavulanic Acid increases the serum concentration level. Drug that reduces gastric acidity may result in lower bioavailability.

Contraindications

  • Known allergy to cephalosporin
  • Pseudomembranous Colitis

Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal discomfort or pain
  • Prolonged administration may result in overgrowth of nonsusceptible microorganisms
  • Rarely (<0.2%): renal dysfunction, anaphylaxis, angioedema, pruritis, rash, serum sickness like urticaria

Pregnancy and Lactation

Avoid in first trimester if possible. Can be used in later pregnancy and excreted into breast milk in small quantities

Precautions and Warnings

Given with care to patients receiving concurrent treatment with potent diuretics & patients with history of colitis

Therapeutic Class

Second generation Cephalosporins

Storage Conditions

Store in a cool, dry place (below 30°C), away from light and moisture. Keep out of the reach of children.

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