Fixim 100 mg/5 ml (Powder for Suspension)

Indications

• Treatment of Upper Respiratory Tract Infections (URTI)
• Treatment of Lower Respiratory Tract Infections
• Treatment of Urinary Tract Infections (UTI)
• Clinical efficacy against Streptococcus pneumonia
• Clinical efficacy against Streptococcus pyogenes
• Clinical efficacy against Escherichia coli
• Clinical efficacy against Proteus mirabilis
• Clinical efficacy against Klebsiella species
• Highly stable in the presence of beta-lactamase enzymes

Pharmacology

• Third generation semisynthetic cephalosporin antibiotic
• Bactericidal against a broad spectrum of gram-positive and gram-negative bacteria
• Interferes with the synthesis of bacterial cell wall
• Highly stable in the presence of beta-lactamase enzyme
• Approximately 40-50% absorption

Dosage & Administration

• Usual course of treatment is 7 days
• May be continued for up to 14 days if required
• Recommended adult dosage is 200-400 mg daily
• Recommended dosage for children is 8 mg/kg/day
• Special dosing for typhoid treatment
• Caution and dose adjustment in elderly and patients with renal impairment

Interaction

• Potential increase in prothrombin times in some patients
• Careful consideration needed for patients receiving anticoagulant therapy

Contraindications

• Hypersensitivity to cephalosporin antibiotics

Side Effects

• Mild and self-limiting adverse reactions
• Frequent gastrointestinal disturbances like diarrhea
• Other gastrointestinal side-effects include nausea, abdominal pain, and vomiting
• Central nervous system effects like headache and dizziness
• Hypersensitivity reactions in the form of rash and urticaria
• Hematological reactions such as thrombocytopenia and leukopenia
• Mild and reversible changes in liver and renal function tests

Pregnancy & Lactation

• No adequate and well-controlled studies in pregnant women
• Caution advised for use during pregnancy
• Unknown excretion in human milk
• Caution advised for use during lactation

Precautions & Warnings

• Caution in patients with known hypersensitivity to other drugs
• Cautious use in penicillin-sensitive patients
• Administration with caution in patients with markedly impaired renal function
• Potential alteration of normal flora of the colon with broad-spectrum antibiotics

Overdose Effects

• Gastric lavage may be indicated in case of overdose
• No specific antidote available
• Not significantly removed by hemodialysis or peritoneal dialysis

Therapeutic Class

• Third generation Cephalosporins

Storage Conditions

• Recommended storage below 30°C temperature
• Protection from light and moisture
• Keep out of the reach of children

Chemical Structure

• Molecular Formula: C16H15N5O7S2
• Visual depiction of chemical structure available

Common Questions about Fixim 100 mg/5 ml Suspension

• Indication for treating bacterial infections
• Common uses for Urinary Tract Infections (UTI) and other conditions
• List of commonly reported side-effects
• Instructions for storage and disposal
• Limitations for treating cold and flu
• No specific dietary instructions
• Not recommended for treating diarrhea
• Safety information for infants and newborns
• Differentiation from penicillin variants
• Known side-effects of causing loose-motion and constipation
• No evidence of interaction with contraception
• Possible interaction with acetaminophen (Paracetamol)
• Time for onset of action and advice if symptoms persist
• Quick tips for dosage and potential side-effects

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