Gento-HC 0.3%+1% (Ear Drop)

10 ml drop: ৳ 75.00

Medicine Details

Category	Details
Generic	Gentamicin hydrocortisone acetate
Company	Gaco pharmaceuticals ltd
Also available as	Gento hc 03 1 cream

Indications

Treatment of chronic suppurative otitis media
Treatment of otitis externa
Prophylactic treatment of otitis externa following trauma
Post-operative local use in surgery to infected mastoid cavities
Treatment for redness, itching, and swelling of the skin

Pharmacology

Gentamicin binds to 30s and 50s ribosomal subunits of susceptible bacteria
Disrupts protein synthesis
Hydrocortisone has anti-inflammatory effects
Hydrocortisone has immunosuppressive effects

Dosage

Instill 2-4 drops in the affected ear three to four times a day
Instill at night or more frequently if required
Apply to the affected area of the skin two or three times per day

Administration

Ear Drops need to shake well immediately before use

Interaction

Additive effect with other neurotoxic and/or nephrotoxic drugs
May potentiate the effect of anticoagulants
Increased risk of hypocalcaemia with bisphosphonates
Increased risk of neuromuscular blockade with botulinum toxin
Thiazides may enhance hyperglycaemia and hypokalaemia caused by corticosteroids
Response to anticoagulants altered
Dose of antidiabetics and antihypertensives needs to be increased

Contraindications

History of hypersensitivity to aminoglycoside
Pregnancy
Hepatic impairment

Side Effects

Allergic contact dermatitis
Transient irritation
Burning
Stinging
Increased redness
Lacrimation

Pregnancy & Lactation

Pregnancy Category- C
Adverse effect on the fetus
No adequate and well-controlled studies in humans

Precautions & Warnings

Concurrent use of neuromuscular blocking agents
Myasthenia gravis
Parkinsonism
Conditions predisposing to ototoxicity and nephrotoxicity
Lactation
Monitor plasma concentrations of gentamicin

Therapeutic Class

Hydrocortisone & Combined preparations
Ophthalmic steroid - antibiotic combined preparations

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