ABO Kit 200 mg+200 mcg (Tablet)
(1+4) tablet kit: ৳ 280.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Mifepristone misoprostol |
| Company | Globe pharmaceuticals ltd |
Indications
- Early Menstrual Regulation (MR)
- Termination of pregnancy up to 9 weeks (63 days) of gestation
Composition
- Each box contains 2 blister strips
- 1 tablet of Mifepristone INN 200 mg
- 4 tablets of Misoprostol USP 200 microgram each
Pharmacology
- Mifepristone: synthetic steroid with anti-progestational activity
- Inhibition of progesterone activity
- Sensitization of myometrium to contraction-inducing activity of prostaglandins
- Misoprostol: synthetic analogue of prostaglandin E1
- Causes myometrial contraction by interacting with specific receptors
Dosage & Administration
- Prescribed by qualified medical professionals
- Mifepristone administration on Day 1
- Misoprostol administration on Day 2
- Post-treatment examination on Day 10-14
Interaction
- Potential interactions involving CYP 3A4 metabolism
- Possible inhibition by Ketoconazole, Itraconazole, Erythromycin, grapefruit juice
Contraindications
- History of allergy/hypersensitivity to Mifepristone, Misoprostol, or other prostaglandin
- Confirmed or suspected ectopic pregnancy
- Undiagnosed adnexal mass
- IUD in place
- Chronic adrenal failure
- Haemorrhagic disorders or concurrent anticoagulant therapy
- Inherited porphyria
Side Effects
- Nausea, vomiting, diarrhea
- Pelvic pain, fainting, headache, dizziness
- Gastro-intestinal side-effects (diarrhea, abdominal pain, nausea)
Pregnancy & Lactation
- Mifepristone indicated for Menstrual Regulation (MR)
- Risk of fetal malformation resulting from the treatment
Precautions & Warnings
- Not to be given to anyone else
- IUD should be removed before treatment
- Surgical termination recommended in case of failure
Use in Special Populations
- Use in Patients with Hepatic Impairment
- Use in Patients with Renal Impairment
Overdose Effects
- No serious adverse reactions reported in tolerance studies
- Clinical signs that may indicate an overdose
Therapeutic Class
Drugs acting on the Uterus, Prostaglandin analogues
Storage Conditions
Cool, dry place, protected from light