Cidogrel 75 mg (Tablet)
Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clopidogrel bisulphate |
| Company | Apex pharmaceuticals ltd |
Indications
- Reduces rate of myocardial infarction (MI)
- Reduces rate of stroke
- Effective in non-ST-segment elevation ACS
- Effective in ST-elevation myocardial infarction (STEMI)
- Reduces rate of recent MI and recent stroke
- Reduces rate of established peripheral arterial disease
Pharmacology
- Clopidogrel is a prodrug
- Inhibits platelet activation and aggregation
- Irreversible binding to P2Y12 class of ADP receptors on platelets
- Dose-dependent inhibition of platelet aggregation
Dosage & Administration
- 300 mg oral loading dose for acute coronary syndrome
- 75 mg once daily for recent MI, recent stroke, or established peripheral arterial disease
- Oral administration with or without food
Interaction
- Increases risk of bleeding with NSAIDs, warfarin, SSRIs, SNRIs
- Avoid concomitant use with CYP2C19 inhibitors like omeprazole or esomeprazole
- Increases plasma concentrations of Repaglinide when used concomitantly
Contraindications
- Hypersensitivity to the drug substance or any component
- Active pathological bleeding such as peptic ulcer or intracranial hemorrhage
Side Effects
- Common side effects include bleeding, diarrhea, gastrointestinal discomfort, haemorrhage, skin reactions
- Rare side effects include acquired haemophilia, anemia, angioedema, arthritis, bone marrow disorders
Pregnancy & Lactation
- Use in pregnancy only if clearly needed
- Unknown excretion in human breast milk
- Decision to discontinue nursing or drug should consider importance of the drug to the mother
Precautions & Warnings
- Metabolism impaired by genetic variations in CYP2C19 and drugs that inhibit CYP2C19
- Inhibits platelet aggregation for lifetime of the platelet
- Increased risk of bleeding
- Discontinuation increases risk of cardiovascular events
- Thrombotic Thrombocytopenic Purpura (TTP) may require urgent treatment
Use in Special Populations
- Safety and effectiveness not established in pediatric populations
- No dosage adjustment necessary in elderly patients
Overdose Effects
- May lead to bleeding complications
- Platelet transfusion may restore clotting ability
Therapeutic Class
- Anti-platelet drugs
Storage Conditions
- Keep below 30°C temperature in a dry place
- Protected from light
- Do not freeze
- Keep out of the reach of children