Farin 2 mg (Tablet)
Unit Price: ৳ 2.00 (10 x 10: ৳ 200.00)
Strip Price: ৳ 20.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Warfarin sodium |
| Company | Concord pharmaceuticals ltd |
| Also available as |
Indications
- Prophylaxis and/or treatment of thromboembolic complications associated with atrial fibrillation and/or cardiac valve replacement
- Indicated to reduce the risk of death, recurrent myocardial infarction, and thromboembolic events such as stroke or systemic embolization after myocardial infarction
- Prophylaxis and treatment of venous thrombosis and pulmonary embolism
- Transient ischaemic attacks
Description
- Anticoagulant that inhibits the synthesis of vitamin K dependent clotting factors
Pharmacology
- Acts as a vitamin K antagonist to inhibit the production of vitamin K by vitamin K epoxide reductase
Dosage & Administration
- Usual adult induction dose of 10 mg daily for 2 days
- Subsequent maintenance dose depends upon the prothrombin time (INR)
- Maintenance dose range for adults: 3 to 9 mg daily
- Initial dose for children <18 years old: 0.1 mg.kg-1.d-1
Interaction
- Oral anticoagulants have potential for clinically significant drug interactions
Contraindications
- Cannot be administered in cases of actual or potential hemorrhagic conditions
- Severe hepatic or renal disease
- Pregnancy
- Known hypersensitivity to warfarin
- Bacterial endocarditis
Side Effects
- Principal adverse effect: hemorrhage
- Other adverse reactions: nausea, vomiting, diarrhea, hypersensitivity, rash, alopecia, unexplained drop in haematocrit, 'purple toes', skin necrosis, jaundice, hepatic dysfunction
Pregnancy & Lactation
- Contraindicated in the first trimester of pregnancy due to risk of teratogenicity
- Not recommended for use in women who are or may become pregnant
Precautions & Warnings
- Periodic determination of prothrombin time (PT)/international normalized ratio (INR) is essential
- Numerous factors can influence response to anticoagulants including travel, changes in diet, environment, physical state and medication
- Monitoring response with additional PT/INR determination after hospital discharge and when other medications are initiated, discontinued or taken irregularly
Overdose Effects
- Excessive depression of coagulation activity can be corrected by temporary withdrawal of warfarin
- Supplementation with vitamin K may be required
Therapeutic Class
- Anti-coagulants, Oral Anti-coagulants
Storage Conditions
- Do not store above 30°C. Keep away from light and out of the reach of children