Holicef 1 gm/vial (IM Injection)

1 gm vial: ৳ 175.00

Medicine Details

Category	Details
Generic	Ceftriaxone sodium
Company	Concord pharmaceuticals ltd
Also available as	Holicef 1 gm injection Holicef 2 gm injection Holicef 500 mg injection

Indications

Lower respiratory tract infections
Acute Bacterial Otitis Media
Skin and skin structure infections
Urinary tract infections
Gonorrhea
Bacterial Septicemia
Bone and joint infections
Meningitis
Prevention of postoperative infections
Perioperative prophylaxis of infections associated with surgery

Pharmacology

Broad-spectrum parenteral cephalosporin antibiotic
Bactericidal activity
Interferes with the synthesis of bacterial cell wall
High stability in the presence of beta lactamases
Long plasma elimination half-life of 6 to 9 hours
Not metabolized in the body
Excreted unchanged in urine and bile

Dosage

1 to 2 gm intravenous or intramuscular administration once a day
Maximum dose: 4 gm/day for adults
50 to 75 mg/kg intravenous or intramuscular administration once a day for infants and children (01 month or older)
Maximum dose: 2 gm/day for infants and children
Duration of therapy: 4 to 14 days

Administration

Dissolved in Lidocaine HCI 1% injection for intramuscular injection
Dissolved in Water for injection for intravenous injection
Administered over 2-4 minutes for intramuscular or intravenous injection
Tubing infusion over a period of 30 minutes
High protein binding of 95%

Interaction

No drug interactions reported

Contraindications

Hypersensitivity to cephalosporin antibiotics

Side Effects

Gastro-intestinal effects
Cutaneous reactions
Hematologic reactions
Hepatic reactions
CNS reactions
Local phlebitis following intravenous administration

Pregnancy & Lactation

Safety in human pregnancy not established

Precautions & Warnings

Potential for anaphylactic shock
Gallbladder sludge detection
Blood picture should be checked during prolonged treatment

Use in Special Populations

Avoid in neonates if premature or newborn (up to 28 days of age)

Overdose Effects

No specific antidote

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Store in a cool, dry place below 30°C, away from light & moisture

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