Holicef 1 gm/vial (IM Injection)
1 gm vial: ৳ 175.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Concord pharmaceuticals ltd |
| Also available as |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
- Broad-spectrum parenteral cephalosporin antibiotic
- Bactericidal activity
- Interferes with the synthesis of bacterial cell wall
- High stability in the presence of beta lactamases
- Long plasma elimination half-life of 6 to 9 hours
- Not metabolized in the body
- Excreted unchanged in urine and bile
Dosage
- 1 to 2 gm intravenous or intramuscular administration once a day
- Maximum dose: 4 gm/day for adults
- 50 to 75 mg/kg intravenous or intramuscular administration once a day for infants and children (01 month or older)
- Maximum dose: 2 gm/day for infants and children
- Duration of therapy: 4 to 14 days
Administration
- Dissolved in Lidocaine HCI 1% injection for intramuscular injection
- Dissolved in Water for injection for intravenous injection
- Administered over 2-4 minutes for intramuscular or intravenous injection
- Tubing infusion over a period of 30 minutes
- High protein binding of 95%
Interaction
No drug interactions reported
Contraindications
Hypersensitivity to cephalosporin antibiotics
Side Effects
- Gastro-intestinal effects
- Cutaneous reactions
- Hematologic reactions
- Hepatic reactions
- CNS reactions
- Local phlebitis following intravenous administration
Pregnancy & Lactation
Safety in human pregnancy not established
Precautions & Warnings
- Potential for anaphylactic shock
- Gallbladder sludge detection
- Blood picture should be checked during prolonged treatment
Use in Special Populations
Avoid in neonates if premature or newborn (up to 28 days of age)
Overdose Effects
No specific antidote
Therapeutic Class
Third generation Cephalosporins
Storage Conditions
Store in a cool, dry place below 30°C, away from light & moisture