Holicef 1 gm/vial (IV Injection)

1 gm vial: ৳ 185.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Concord pharmaceuticals ltd
Also available as
Holicef 1 gm injection Holicef 2 gm injection Holicef 500 mg injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

  • Broad-spectrum parenteral cephalosporin antibiotic
  • Bactericidal activity against a wide range of Gram-positive and Gram-negative organisms
  • Interferes with the synthesis of the bacterial cell wall
  • High stability in the presence of beta lactamases
  • Long plasma elimination half-life of about 6 to 9 hours
  • Not metabolized in the body
  • Highly protein bound (95%)

Dosage

  • Usual dose of 1 to 2 gm by intravenous or intramuscular administration once a day
  • Different doses for various infections
  • Suitable for adults, infants, and children over 1 month
  • Recommended duration of therapy
  • Maximum doses for various conditions

Administration

  • Preparation of solutions for intramuscular and intravenous injections
  • Administration over 2-4 minutes
  • Tubing infusion over a period of 30 minutes
  • Patient tolerance test recommended before treatment
  • Freshly reconstituted solution recommended for use

Interaction

  • No reported drug interactions

Contraindications

  • Not to be given to patients with a history of hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea, vomiting, stomatitis, and glossitis
  • Cutaneous reactions including rash, pruritus, urticaria, edema, and erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia, and neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia, and dizziness
  • Rare occurrence of local phlebitis following intravenous administration

Pregnancy & Lactation

  • Safety in human pregnancy has not been established
  • Caution advised when administered to lactating mothers

Precautions & Warnings

  • Potential risk of anaphylactic shock
  • Possibility of gallbladder issues
  • Blood picture should be checked during prolonged treatment

Use in Special Populations

  • Not recommended for neonates if premature and newborn (up to 28 days of age)

Overdose Effects

  • No specific antidote
  • Symptomatic treatment recommended

Therapeutic Class

  • Third generation Cephalosporins

Storage Conditions

  • Vial should be stored in a cool, dry place (below 30° C)
  • Keep away from light and moisture
  • Keep out of the reach of children

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