Holicef 500 mg/vial (IM Injection)

500 mg vial: ৳ 125.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Concord pharmaceuticals ltd
Also available as
Holicef 1 gm injection Holicef 1 gm injection Holicef 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

  • Broad-spectrum parenteral cephalosporin antibiotic
  • Bactericidal activity against a wide range of Gram-positive and Gram-negative organisms
  • Interferes with the synthesis of the bacterial cell wall
  • Relatively long plasma elimination half-life of 6 to 9 hours
  • Not metabolized in the body
  • Highly protein bound (95%)

Dosage

  • Usual dose of 1 to 2 gm by intravenous or intramuscular administration once a day
  • Maximum dose of 4 gm/day
  • Infants and Children dose of 50 to 75 mg/kg intravenous or intramuscular administration once a day
  • Maximum dose for Infants and Children of 2 gm/day
  • Duration of therapy: 4 to 14 days

Administration

  • Preparation for Intramuscular / Intravenous Injections
  • Injection administered over 2-4 minutes
  • Patient tolerance test recommended

Interaction

  • No reported drug interactions

Contraindications

  • Should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea and vomiting, stomatitis and glossitis
  • Cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness
  • Local phlebitis occurs rarely following intravenous administration

Pregnancy & Lactation

  • Safety in human pregnancy not established
  • Caution advised when administered to lactating mothers

Precautions & Warnings

  • Anaphylactic shock requires immediate countermeasures
  • Sludge detected by sonograms of the gallbladder
  • Blood picture should be checked during prolonged treatment

Use in Special Populations

  • Must not be given to neonates if premature and newborn (up to 28 days of age)

Overdose Effects

  • No specific antidote
  • Treatment should be symptomatic

Therapeutic Class

  • Third generation Cephalosporins

Storage Conditions

  • Store in a cool, dry place (below 30° C), away from light & moisture

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