Treptora 50 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Eltrombopag olamine |
| Company | Genvio pharma ltd |
| Also available as |
Indications
- Treatment of thrombocytopenia in patients with persistent or chronic immune thrombocytopenia
- Treatment of thrombocytopenia in patients with hepatitis C infection
- Treatment of severe aplastic anemia
Pharmacology
Eltrombopag Olamine is a small molecule thrombopoietin (TPO) receptor agonist. Eltrombopag interacts with the transmembrane domain of the human TPO-receptor and initiates signaling cascades that induce proliferation and differentiation from bone marrow progenitor cells finally leading to increased platelet production.
Dosage & Administration
- Oral route of administration
- Dosing instructions for persistent or chronic immune thrombocytopenia, hepatitis C associated thrombocytopenia, severe aplastic anemia
- Special dosing considerations for pediatric patients and patients with hepatic impairment
Interaction
- Drug interaction with medication
- Drug interaction with food and others
Contraindications
Contraindicated in patients with known hypersensitivity to eltrombopag or any components of this product
Side Effects
- Anemia
- Nausea
- Pyrexia
- ALT increased
- Cough
- Fatigue
- Headache
- Diarrhea
Pregnancy & Lactation
No sufficient data available to assess any drug-associated risks for major birth defects, miscarriage or adverse maternal or fetal outcomes. Breastfeeding is not recommended during treatment.
Precautions & Warnings
- Increased risk of hepatic decompensation in patients with chronic hepatitis C
- Increased risk of death and progression of myelodysplastic syndromes to acute myeloid leukemia
- Portal vein thrombosis risk in patients with chronic liver disease
- Monitoring of liver function and platelet counts recommended
Use in Special Populations
- Safety and efficacy in pediatric patients below the age of 1 year with ITP not established
- Safety and efficacy in pediatric patients with thrombocytopenia associated with chronic hepatitis C and refractory severe aplastic anemia not established
Overdose Effects
In the event of overdose, platelet counts may increase excessively and result in thrombotic or thromboembolic complications. Consider oral administration of a metal cation containing preparation to chelate eltrombopag and limit absorption.
Therapeutic Class
Haemostatic drugs
Storage Conditions
Store in a cool (below 25°C) and dry place protected from light. Keep away from the reach of children.