Ibakin 400 mg (Tablet)

Unit Price: ৳ 350.00 (3 x 10: ৳ 10,500.00)
Strip Price: ৳ 3,500.00

Medicine Details

Category Details
Generic Imatinib mesylate
Company Genvio pharma ltd
Also available as
Ibakin 100 mg tablet

Indications

  • Philadelphia chromosome positive chronic myeloid leukemia (Ph+CML)
  • Chronic phase
  • Blast crisis
  • Accelerated phase
  • Interferon-alpha therapy
  • Acute lymphoblastic leukemia (ALL)
  • Myelodysplastic/myeloproliferative diseases
  • Systemic mastocytosis
  • Hypereosinophilic syndrome
  • Dermatofibrosarcoma protuberans
  • Gastrointestinal stromal tumors
  • Adjuvant treatment
  • Kit (CD117) positive GIST

Pharmacology

Small molecule protein-tyrosine kinase inhibitor

Absorption and Distribution

Cmax achieved within 2-4 hours post-dose

Metabolism

Mainly metabolized by CYP3A4

Excretion

Predominately in the feces

Dosage & Administration

  • Adults with Ph+ CML CP: 400 mg/day
  • Pediatrics with Ph+ CML CP: 340 mg/m2/day
  • Adults with Ph+ ALL: 600 mg/day
  • Pediatrics with Ph+ ALL: 340 mg/m2/day
  • Adults with MDS/MPD: 400 mg/day
  • Adults with ASM: 100 mg/day or 400 mg/day
  • Adults with HES/CEL: 100 mg/day or 400 mg/day
  • Adults with DFSP: 800 mg/day
  • Adults with metastatic and/or unresectable GIST: 400 mg/day
  • Adjuvant treatment of adults with GIST: 400 mg/day

Interaction

  • Agents Inducing CYP3A Metabolism
  • Agents Inhibiting CYP3A Metabolism
  • Interactions with Drugs Metabolized by CYP3A4
  • Interactions with Drugs Metabolized by CYP2D6

Side Effects

  • Fluid Retention and Edema
  • Hematologic Toxicity
  • Congestive Heart Failure
  • Hepatotoxicity
  • Hemorrhage
  • Gastrointestinal Disorders
  • Hypothyroidism
  • Growth Retardation
  • Tumor Lysis Syndrome
  • Impairments Related to Driving

Pregnancy & Lactation

  • Use effective contraception during treatment
  • Pregnancy warning
  • Breast-feeding warning
  • Fertility impact

Precautions & Warnings

  • Edema
  • Cytopenias
  • Congestive heart failure
  • Hepatotoxicity
  • Hemorrhage
  • Cardiogenic shock
  • Dermatologic reactions
  • Hypothyroidism
  • Fetal harm
  • Growth retardation
  • Tumor Lysis Syndrome
  • Motor vehicle accidents
  • Renal Toxicity

Overdose Effects

  • Nausea
  • Vomiting
  • Diarrhoea
  • Rash
  • Edema
  • Weakness
  • Myalgia
  • Gastrointestinal pain

Therapeutic Class

Targeted Cancer Therapy, Tyrosine Kinase Inhibitor

Storage Conditions

Store below 30°C, in a cool and dry place

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