Flavona 50 mg (Capsule)
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | Rephco pharmaceuticals ltd |
Title
Flavona (Fluconazole) Tablet
Categories
- Medicine
- Antifungal
- Antimycotic
- Pharmaceutical
Description
Flavona is indicated for the treatment of various fungal infections including vaginal/oropharyngeal/esophageal candidiasis, tinea corporis/cruris/pedis, onychomycosis, invasive candidal and cryptococcal infections, prevention of fungal infections in immunocompromised patients, and more. It is a triazole antifungal agent, inhibiting fungal cytochrome P-450 dependent enzymes.
Dimensions
Varies by tablet size
Color options
- White
Functions
- Treats fungal infections
- Potent inhibitor of fungal enzymes
Materials
- Fluconazole
- Inactive ingredients (varies by tablet)
Technical specifications
- Adults:
- Vaginal Candidiasis: 150 mg as a single dose
- Oropharyngeal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14 days
- Oesophageal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14-30 days
- Tinea corporis/cruris/pedis: 150 mg weekly for 4-6 weeks
- Kerion: 50 mg daily for 20 days
- Pityriasis versicolor: 400 mg as a single dose
- Onychomycosis: 150 mg weekly for 12 months
- Invasive candidal and cryptococcal infections: 400 mg on first day then 200-400 mg daily
- Children:
- Superficial Candidiasis: 1-2 mg/kg daily
- Systemic Candidiasis & Cryptococcal infection: 3-6 mg/kg daily
- Specific Population:
- Elderly patients: Normal dose if no renal impairment
- Renal Impairment: Dosage interval modification based on creatinine clearance
Design elements
- Tablets
Usability features
- Oral administration
Interaction
- Warfarin: May increase prothrombin time
- Sulphonyl ureas: May prolong serum half-life
- Hydrochlorothiazide: May increase fluconazole plasma concentrations
- Phenytoin: May increase phenytoin levels
- Rifampicin: May decrease fluconazole levels
- Oral contraceptives: Unlikely to affect efficacy at lower doses
- Cyclosporine: May slowly increase cyclosporine concentrations
- Food/cimetidine/antacids: No clinically significant impairment of fluconazole absorption
- Theophylline: May decrease theophylline clearance
Contraindications
- Known hypersensitivity to Fluconazole or related triazole compounds
Side effects
- Nausea
- Abdominal discomfort
- Diarrhea
- Flatulence
- Rarely rash or anaphylaxis
Pregnancy and lactation
Not recommended in pregnancy or breastfeeding unless adequate contraception is employed
Precautions and warnings
- Underlying diseases: May cause abnormalities in hepatic, renal, and biochemical function tests
- Severe cutaneous reactions: Rarely encountered, should discontinue if rash develops
- Use in lactation: Not recommended
- Driving and machinery use: Unlikely to impair ability
Special populations
- Elderly: Normal dose if no renal impairment
- Renal Impairment: Dosage interval modification based on creatinine clearance
Overdose effects
Supportive measures and symptomatic treatment, forced volume diuresis may increase elimination rate, haemodialysis decreases plasma levels by approximately 50%
Therapeutic class
Drugs for subcutaneous and mycoses
Storage conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.