Flucoron 50 mg (Capsule)
Unit Price: ৳ 7.50 (30's pack: ৳ 225.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | Rn pharmaceuticals |
Title
- Flucoron
Categories
- Antifungal
- Medication
- Pharmacology
- Therapeutic Class
Description
- Potent inhibitor of fungal cytochrome P-450 dependent enzymes
- Excreted predominantly in the urine
- Well tolerated
- Should not be used in patients with known hypersensitivity to Fluconazole
- Adverse fetal effects seen in animals only at dose levels associated with maternal toxicity
- Found in human breast milk at concentrations similar to plasma
- Unlikely to impair a patient's ability to drive or use machinery
Color Options
- N/A
Dimensions
- N/A
Functions
- Treatment of Vaginal Candidiasis
- Treatment of Oropharyngeal Candidiasis
- Treatment of Oesophageal Candidiasis
- Treatment of Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
- Treatment of Kerion
- Treatment of Pityriasis versicolor
- Treatment of Onychomycosis
- Treatment of Invasive candidal infections and cryptococcal infections (including meningitis)
- Prevention of cryptococcal meningitis
- Prevention of fungal infections in immunocompromised patients
- Systemic Candidiasis and Cryptococcal infection
- Superficial Candidiasis
- Treatment of Fungal urinary tract infections
- Treatment of Disseminated candidiasis
- Prophylaxis for fungal infection in neutropenic cancer patients
- Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis
Materials
- N/A
Technical Specifications
- Adult Dosage: Varies based on indication
- Child Dosage: Varies based on indication and weight
- Renal Impairment Dosage Interval: Varies based on creatinine clearance
Design Elements
- N/A
Usability Features
- Experience indicates minimal impairment of a patient's ability to drive or use machinery
- Excretion predominantly in the urine
Side Effects
- Nausea
- Abdominal discomfort
- Diarrhoea
- Flatulence
- Rarely encountered rash
- Rarely reported anaphylaxis
Pregnancy & Lactation
- Adverse fetal effects seen in animals only at high dose levels
- Not recommended for use in pregnancy or in women of childbearing potential unless adequate contraception is employed
- Found in human breast milk at concentrations similar to plasma, not recommended during lactation
Dosage & Administration
- Varies based on indication, age, and renal impairment
- Adult Dosage: Oral or IV administration
- Child Dosage: Oral administration
- Elderly Patient Dosage: Normal dose should be used if no evidence of renal impairment
Precautions & Warnings
- Observation of abnormalities in hepatic, renal, haematological, and biochemical function tests in some patients
- Rare development of exfoliative cutaneous reactions
- Close monitoring and possible discontinuation in the event of rashes
- Not recommended for use in nursing mothers
Interaction
- Increased prothrombin time with warfarin administration
- Prolonged serum half-life of oral sulphonyl ureas
- Increased plasma concentrations of fuconazole by co-administration of multiple-dose hydrochlorothiazide
- Possible increase in phenytoin levels
- Possible decrease in AUC and shorter half-life of fuconazole with rifampicin administration
- No clinically significant impairment of absorption with food, cemetidine, antacids, or following total body irradiation
- Decrease in plasma clearance of theophyline by 18%
Indications
- Vaginal Candidiasis
- Oropharyngeal Candidiasis
- Oesophageal Candidiasis
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
- Kerion
- Pityriasis versicolor
- Onychomycosis
- Invasive candidal infections and cryptococcal infections (including meningitis)
- Prevention of cryptococcal meningitis
- Prevention of fungal infections in immunocompromised patients
- Systemic Candidiasis and Cryptococcal infection
- Superficial Candidiasis
- Fungal urinary tract infections
- Disseminated candidiasis
- Prophylaxis for fungal infection in neutropenic cancer patients
- Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis
Use in Special Populations
- Elderly Patient Dosage
- Renal Impairment Dosage Interval
- Excreted predominantly in the urine
Overdose Effects
- Supportive measures and symptomatic treatment
- Possible gastric lavage if necessary
- Increased elimination rate with forced volume diuresis
- Approximately 50% decrease in plasma levels with haemodialysis
Contradictions
- Known hypersensitivity to Fluconazole or related triazole compounds
Storage Conditions
- Dry place away from light and heat
- Out of the reach of children