A-Kit 200 mg+200 mcg (Tablet)

(1+4) tablet kit: ৳ 300.00

Medicine Details

Indications

  • early Menstrual Regulation (MR)
  • termination of pregnancy up to 9 weeks gestation

Composition

  • 2 blister strips
  • 1 tablet of Mifepristone INN 200 mg
  • 4 tablets of Misoprostol USP 200 microgram each

Pharmacology

  • anti-progestational activity
  • sensitization of myometrium to contraction-inducing activity of prostaglandins
  • myometrial contraction by interacting with specific receptors
  • change in calcium concentration initiating muscle contraction

Dosage & Administration

  • Mifepristone administration: One tablet of Mifepristone (200 mg) taken under supervision
  • Misoprostol administration: four 200 microgram tablets buccally or sublingually
  • Post-treatment examination within 10-14 days

Interaction

  • Mifepristone metabolism inhibited by Ketoconazole, Itraconazole, Erythromycin, grapefruit juice
  • Misoprostol has no clinically significant effects on aspirin

Contraindications

  • History of allergy to Mifepristone, Misoprostol, or prostaglandin
  • confirmed or suspected ectopic pregnancy
  • IUD in place
  • chronic adrenal failure
  • haemorrhagic disorders
  • inherited porphyria

Side Effects

  • nausea
  • vomiting
  • diarrhoea
  • pelvic pain
  • fainting
  • headache
  • dizziness
  • asthenia
  • diarrhoea
  • abdominal pain
  • flatulence
  • shivering
  • hyperthermia
  • severe vaginal bleeding
  • shock
  • uterine rupture

Pregnancy & Lactation

  • Mifepristone indicated for Menstrual Regulation (MR)
  • no approved indication during lactation
  • consultation for breastfeeding women

Precautions & Warnings

  • Not to be given to anyone else
  • IUD removal before treatment
  • Surgery recommended if treatment fails

Use in Special Populations

  • Decreased Misoprostol dose for hepatic impairment
  • Reduced Misoprostol dose if usual dose not tolerated in renal impairment

Overdose Effects

  • No serious adverse reactions reported for Mifepristone overdose
  • Supportive therapy for Misoprostol overdose symptoms

Therapeutic Class

  • Drugs acting on the Uterus
  • Prostaglandin analogues

Storage Conditions

  • Store in a cool and dry place
  • protected from light

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