A-Kit 200 mg+200 mcg (Tablet)
(1+4) tablet kit: ৳ 300.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Mifepristone misoprostol |
| Company | Acme laboratories ltd |
Indications
- early Menstrual Regulation (MR)
- termination of pregnancy up to 9 weeks gestation
Composition
- 2 blister strips
- 1 tablet of Mifepristone INN 200 mg
- 4 tablets of Misoprostol USP 200 microgram each
Pharmacology
- anti-progestational activity
- sensitization of myometrium to contraction-inducing activity of prostaglandins
- myometrial contraction by interacting with specific receptors
- change in calcium concentration initiating muscle contraction
Dosage & Administration
- Mifepristone administration: One tablet of Mifepristone (200 mg) taken under supervision
- Misoprostol administration: four 200 microgram tablets buccally or sublingually
- Post-treatment examination within 10-14 days
Interaction
- Mifepristone metabolism inhibited by Ketoconazole, Itraconazole, Erythromycin, grapefruit juice
- Misoprostol has no clinically significant effects on aspirin
Contraindications
- History of allergy to Mifepristone, Misoprostol, or prostaglandin
- confirmed or suspected ectopic pregnancy
- IUD in place
- chronic adrenal failure
- haemorrhagic disorders
- inherited porphyria
Side Effects
- nausea
- vomiting
- diarrhoea
- pelvic pain
- fainting
- headache
- dizziness
- asthenia
- diarrhoea
- abdominal pain
- flatulence
- shivering
- hyperthermia
- severe vaginal bleeding
- shock
- uterine rupture
Pregnancy & Lactation
- Mifepristone indicated for Menstrual Regulation (MR)
- no approved indication during lactation
- consultation for breastfeeding women
Precautions & Warnings
- Not to be given to anyone else
- IUD removal before treatment
- Surgery recommended if treatment fails
Use in Special Populations
- Decreased Misoprostol dose for hepatic impairment
- Reduced Misoprostol dose if usual dose not tolerated in renal impairment
Overdose Effects
- No serious adverse reactions reported for Mifepristone overdose
- Supportive therapy for Misoprostol overdose symptoms
Therapeutic Class
- Drugs acting on the Uterus
- Prostaglandin analogues
Storage Conditions
- Store in a cool and dry place
- protected from light