Dolonil 50 mg (Capsule)

Unit Price: ৳ 7.55 (2 x 10: ৳ 151.00)

Strip Price: ৳ 75.50

Medicine Details

Category	Details
Generic	Tramadol hydrochloride
Company	Acme laboratories ltd
Also available as	Dolonil 100 mg injection Dolonil sr 100 mg tablet

Indications

Postoperative pain
Colic and spastic pain
Cancer pain
Joint pain
Neck and back pain
Pain associated with osteoporosis

Pharmacology

Tramadol is a centrally acting synthetic analgesic compound. It inhibits the reuptake of neurotransmitters- serotonin and noradrenaline. It modifies the transmission of pain impulses by activating both descending serotonergic pathways and noradrenergic pathways involved in analgesia.

Dosage & Administration

Capsule or Tablet: Usual doses are 50 to 100 mg every four to six hours. Total daily dosage by mouth should not exceed 400 mg.
Sustained Release Capsule or Tablet: One SR capsule or tablet every 12 hours. Total daily dosage by mouth should not exceed 400 mg.
Injection: A dose of 50-100 mg may be given every 4 to 6 hours by intramuscular or by intravenous infusion. Total daily dose should not exceed 600 mg.
Suppository: For adults usual dose is 100 mg Tramadol Hydrochloride 6 hourly. Total daily dose varies.

Interaction

In general, physician need not be concerned about drugs interacting with Dolonil. Concomitant administration of carbamazepine with Dolonil causes a significant increase in Dolonil metabolism.

Contraindications

Tramadol is contraindicated in persons having hypersensitivity to this drug, and acute intoxication with certain substances.

Side Effects

Dizziness/vertigo
Nausea
Constipation
Headache
Somnolence
Vomiting
Pruritus
CNS stimulation
Asthenia
Sweating
Dyspepsia
Dry mouth
Diarrhea
Malaise
Allergic reaction
Weight loss
Vasodilatation
Palpitations
Abdominal pain
Anorexia
Flatulence
GI bleeding
Hepatitis
Stomatitis

Pregnancy & Lactation

Safe use of Tramadol in pregnancy has not been established. Tramadol should not be administered during breastfeeding.

Precautions & Warnings

Respiratory depression: Tramadol should be administered cautiously in patients at risk for respiratory depression.
Opioid dependence: Dolonil is not recommended for patients who are dependent on opioids.
Concomitant CNS depressants: Dolonil should be used with caution and in reduced dosages when administering to patients receiving CNS depressants.
Concomitant MAO inhibitors: Dolonil should be used with great caution in patients taking MAO inhibitors.
Increased intracranial pressure or head injury: Dolonil should be used with caution in patients with increased intracranial pressure or head injury.

Use in Special Populations

In children from the age of 1 year Dolonil can be given in a dose of 1-2 mg/kg body weight.
Suppository (100 mg Dolonil) should not be administered in children and adolescents below the age of 14 years.
Dolonil 100 mg SR Capsules have not been studied in children.

Therapeutic Class

Opioid analgesics

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.