Dolonil SR 100 mg (Tablet (Sustained Release))

Unit Price: ৳ 25.06 (2 x 8: ৳ 401.00)
Strip Price: ৳ 200.50

Medicine Details

Category Details
Generic Tramadol hydrochloride
Company Acme laboratories ltd
Also available as
Dolonil 100 mg injection Dolonil 50 mg capsule

Indications

  • Treatment of moderate to severe painful conditions
  • Postoperative pain
  • Colic and spastic pain
  • Cancer pain
  • Joint pain
  • Neck and back pain
  • Pain associated with osteoporosis

Pharmacology

  • Centrally acting synthetic analgesic compound
  • Inhibits the reuptake of neurotransmitters
  • Modifies transmission of pain impulses
  • Stimulation of mu-opioid receptors
  • Modulation of central monoaminergic inhibitory pathways

Dosage & Administration

  • Usual doses 50 to 100 mg every four to six hours
  • Initial dose of 100 mg for acute pain
  • Initial dose of 50 mg for chronic painful conditions
  • Total daily dosage by mouth should not exceed 400 mg
  • Sustained Release Capsule or Tablet dosage every 12 hours
  • Injection dosage of 50-100 mg every 4 to 6 hours
  • Suppository dosage of 100 mg Tramadol Hydrochloride 6 hourly
  • Higher daily doses for cancer pain and severe pain after operations

Interaction

  • No concern about most drugs interacting with Dolonil SR
  • Monoamine oxidase (MAO) inhibitors not recommended for combination with Dolonil SR
  • Concomitant administration of carbamazepine causes a significant increase in Dolonil SR metabolism

Contraindications

  • Hypersensitivity to the drug
  • Acute intoxication with specific substances

Side Effects

  • Common side effects: dizziness/vertigo, nausea, constipation, headache, somnolence, vomiting
  • Less common side effects: malaise, allergic reaction, weight loss, GI bleeding, hepatitis
  • Various other side effects including CNS stimulation, dyspepsia, diarrhea, etc.

Pregnancy & Lactation

  • Safe use during pregnancy not established
  • Tramadol crosses the placenta
  • Not recommended during breastfeeding due to detection in breast milk

Precautions & Warnings

  • Cautious administration in patients at risk for respiratory depression
  • Not recommended for patients dependent on opioids
  • Use with caution and in reduced dosages when administering with CNS depressants
  • Use with caution in patients taking MAO inhibitors
  • Use with caution in patients with increased intracranial pressure or head injury and patients with acute abdominal conditions

Use in Special Populations

  • Can be given in children from the age of 1 year
  • Suppository not to be administered in children and adolescents below the age of 14 years
  • 100 mg SR Capsules not studied in children

Therapeutic Class

  • Opioid analgesics

Storage Conditions

  • Keep below 30°C temperature
  • Keep away from light and moisture
  • Keep out of the reach of children

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