Metorax 10 mg (Tablet)
Unit Price: ৳ 15.00 (3 x 10: ৳ 450.00)
Strip Price: ৳ 150.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Methotrexate |
| Company | Renata limited |
| Also available as |
Indications
- Treatment of gestational choriocarcinoma
- Treatment of chorioadenoma destruens
- Treatment of hydatidiform mole
- Acute lymphoblastic leukemia
- Advanced stage non-Hodgkin’s lymphomas
- Breast cancer
- Epidermoid cancers of the head and neck
- Mycosis fungoides
- Lung cancer
- Rheumatoid arthritis
- Polyarticular-course juvenile rheumatoid arthritis
- Psoriasis
- Symptomatic control of severe psoriasis
Pharmacology
Inhibits dihydrofolic acid reductase, interferes with DNA synthesis, repair, and cellular replication, more sensitive in actively proliferating tissues, used to control the psoriatic process
Dosage
- Neoplastic Diseases:
- Orally or intramuscularly in doses of 15 to 30 mg daily for a five-day course
- Induction dose for acute lymphoblastic leukemia: 3.3 mg/m2 in combination with prednisone 60 mg/m2 daily for 4 to 6 weeks
- Maintenance dose for acute lymphoblastic leukemia: Orally or IM administration 2 times a week in total weekly doses of 30 mg/m2
- Lymphoma dosage varies based on the stage and type of tumor
- Breast Cancer dosage: 40 mg/m 2 intravenously on the 1st and 8th day every 4 weeks in combination with cyclophosphamide and fluoracil for 6-12 cycles
- Adult Rheumatoid Arthritis: Single doses of 7.5 mg once per week, maximum dose: 20 mg/week in adults
- Polyarticular-Course Juvenile Rheumatoid Arthritis: 10 mg/m2 once weekly
- Psoriasis: Single dose of 10 to 25 mg once per week, maximum dose: 30 mg/week
Administration
Should be taken on an empty stomach, may be taken with meals to reduce GI discomfort, avoid taking with milk-rich products
Interaction
- NSAIDs
- Salicylates
- Phenylbutazone
- Phenytoin
- Sulfonamides
- Toxicity increased with Penicillin, Theophylline, Probenecid, Azathioprine, Retinoids
- Increased risk of hepatotoxicity with Sulfasalazine
- Caution with Cisplatin
- Increases plasma levels of mercaptopurine with Mercaptopurine
- Decreased intestinal absorption with Tetracycline, Chloramphenicol, Nonabsorbable Broad Spectrum Antibiotics
- Decreases response to systemically administered Metorax with Vitamin preparations containing folic acid or its derivatives
- Rarely increases bone marrow suppression with Trimethoprim/Sulfamethoxazole
Contraindications
- Alcoholism, alcoholic liver disease, or other chronic liver disease
- Immunodeficiency syndromes
- Pre-existing blood dyscrasias
- Hypersensitivity to methotrexate
- Pregnant women with psoriasis or rheumatoid arthritis
- Women of childbearing potential
- Nursing mothers
Side Effects
- Ulcerative stomatitis
- Leukopenia
- Nausea
- Abdominal distress
- Malaise
- Fatigue
- Chills and fever
- Dizziness
- Decreased resistance to infection
- Impairment of fertility
- Oligospermia
- Menstrual dysfunction
Pregnancy & Lactation
US FDA Pregnancy Category X, contraindicated in nursing mothers
Precautions & Warnings
- Metorax formulations and diluents containing preservatives must not be used for intrathecal or high dose Metorax therapy
- Close monitoring for toxic effects
- Adverse reactions should lead to reduction in dosage or discontinuation
- Caution in reinstituting therapy
- Evaluation required for serious liver toxicity with persistent liver function test abnormalities
- Folate deficiency may increase Metorax toxicity
Use in Special Populations
- Pediatric patients benefits should be weighed against potential risk
- Geriatric patients should be closely monitored for early signs of toxicity
Overdose Effects
Leucovorin is indicated to diminish the toxicity and counteract the effect of inadvertently administered overdosages of Metorax
Therapeutic Class
Antidote preparations, Immunosuppressant
Storage Conditions
Store at a temperature not exceeding 30°C in a dry place, protect from light and moisture