Easium 10 mg/2 ml (IM/IV Injection)
2 ml ampoule: ৳ 7.00 (5 x 5: ৳ 175.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Diazepam |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Short-term treatment of mild to moderate anxiety
- Short-term treatment of excitation
- Short-term treatment of agitation
- Short-term treatment of fear
- Short-term treatment of aggressiveness
- Anxiety reactions caused by stressed conditions
- Anxiety states with somatic expression
- Acute alcohol withdrawal
- Status epilepticus
- Premedication for surgical procedures
- Febrile convulsions
- Insomnia of hospitalized patients
Description
- Benzodiazepine derivative
- Safe tranquillizer
- Anxiolytic
- Anticonvulsant
- Central muscle relaxant
- Widely used in obstetrics
- Control of status epilepticus
Pharmacology
- Attaches to specific site on GABA receptor
- Potentiates the effect of GABA
- Opens chloride ion channels into cells
- Rapid and complete absorption after oral administration
- Peak plasma concentration reaches within 15-90 minutes
- Mean plasma half-life of 30 hours
- 98-99% plasma protein binding
- Metabolized in the liver
- Traces of unchanged drug excreted in urine
- Metabolites excreted through bile into intestine
Dosage & Administration
- Oral administration for anxiety
- Oral administration for insomnia associated with anxiety
- Oral administration for night terrors and somnambulism in children
- IM/slow IV injection for severe acute anxiety
- IM/slow IV injection for control of acute panic attacks
- IM/slow IV injection for acute alcohol withdrawal
- IM/slow IV injection for febrile convulsions in children
- Rectal administration for children
Interaction
- Concomitant intake with alcohol not recommended
- Increased sedation with concomitant use of neuroleptics, hypnotics, sedative antihistamines, and CNS depressants
- Easium clearance increased by concomitant administration of phenobarbitone
- Easium clearance decreased by administration of cimetidine
- Inhibition of Easium metabolism by omeprazole and isoniazid
Contraindications
- Contraindicated in myasthenia gravis
- Contraindicated in pulmonary insufficiency
- Contraindicated in respiratory depression
- Contraindicated in hypersensitivity to benzodiazepine
Side Effects
- Somnolence
- Dizziness
- Lightheadedness
- Confusion
- Ataxia
Pregnancy & Lactation
- Crosses placental barrier
- Passes into breast milk
- Avoid if possible during pregnancy and lactation
- US FDA pregnancy category D
Precautions & Warnings
- Prolonged use should be avoided
- Abrupt withdrawal should be avoided
- Use with caution in respiratory disease
- Use with caution in muscle weakness
- Use with caution in history of drug or alcohol abuse
- Use with caution in hepatic impairment
- Use with caution in renal impairment
Overdose Effects
- Sedation
- Muscle weakness
- Profound sleep
- Paradoxical excitation
- Ataxia
- Hypotonia
- Hypotension
- Respiratory depression
- Coma
- Death
Therapeutic Class
- Benzodiazepine sedatives
- Centrally acting skeletal muscle relaxants
- Primary anti-epileptic drugs
Storage Conditions
- Store in cool place (below 25˚C)
- Store in dry place
- Store protected from light