Bumecard 2 mg/4 ml (IM/IV Injection)

2 mg ampoule: ৳ 30.00 (1 x 5: ৳ 150.00)

Medicine Details

Category Details
Generic Bumetanide
Company Incepta pharmaceuticals ltd
Also available as
Bumecard 1 mg tablet Bumecard 5 mg tablet

Indications

  • Treatment of edema associated with congestive heart failure
  • Treatment of edema associated with hepatic and renal disease
  • Treatment of edema associated with nephrotic syndrome

Pharmacology

  • Rapid onset and short duration of action
  • Equivalent diuretic potency to approximately 40 mg furosemide
  • Major site of action: ascending limb of the loop of Henle
  • Inhibits sodium and chloride reabsorption in the ascending limb
  • Possible additional action in the proximal tubule
  • No noticeable action on the distal tubule

Dosage & Administration

  • Oral dosage: 1 mg in the morning, with possible repeat after 6-8 hours
  • IV Injection dosage: 1-2 mg, with possible repeat after 20 minutes
  • IV Infusion dosage: 2-5 mg over 30-60 minutes
  • IM Injection dosage: 1 mg initially, with adjustment according to response
  • Paediatric use: Safety and effectiveness not established below age 18

Interaction

  • Contraindicated with lithium and probenecid
  • Not recommended with indomethacin
  • May potentiate antihypertensive drugs
  • No effect on digoxin blood levels
  • No effect on warfarin metabolism

Contraindications

  • Severe hypokalaemia
  • Severe hyponatraemia
  • Anuria
  • Comatose and precomatose states associated with liver cirrhosis
  • Renal failure

Side Effects

  • Muscle cramps
  • Dizziness
  • Hypotension
  • Headache
  • Nausea
  • ECG changes
  • Musculoskeletal pain
  • Abdominal pain
  • Renal failure
  • Thrombocytopenia
  • Others

Pregnancy & Lactation

  • Pregnancy Category C
  • No adequate and well controlled studies in pregnant women
  • Unknown excretion in human milk

Precautions & Warnings

  • Periodic measurement of serum potassium
  • Consideration of potassium supplements or potassium sparing diuretics

Use in Special Populations

  • Safety and effectiveness not established in paediatric patients below age 18

Overdose Effects

  • Acute profound water loss
  • Volume and electrolyte depletion
  • Dehydration
  • Reduction of blood volume
  • Circulatory collapse
  • Vascular thrombosis and embolism
  • Treatment: replacement of fluid and electrolyte losses

Therapeutic Class

  • Loop diuretics

Storage Conditions

  • Keep below 30°C temperature
  • Away from light and moisture
  • Keep out of the reach of children

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