Urinom MR 0.4 mg (Capsule (Modified Release))

Unit Price: ৳ 10.00 (5 x 6: ৳ 300.00)
Strip Price: ৳ 60.00

Medicine Details

Category Details
Generic Tamsulosin hydrochloride
Company Opsonin pharma ltd
Also available as
Urinom 04 mg tablet

Indications

  • Treatment of functional symptoms of Benign Prostatic Hyperplasia (BPH)

Pharmacology

  • Selective alpha1 adrenoceptor blocking agent
  • Improvement in urine flow rate
  • Reduction in symptoms of BPH
  • Absorption percentage (90%) following oral administration under fasting conditions
  • Time to maximum concentration (Tmax) reached by four to five hours under fasting conditions
  • Extensively metabolized by cytochrome P 450 enzymes in the liver
  • Elimination half-life ranges from five to seven hours
  • Apparent half-life is approximately 9 to 15 hours

Dosage & Administration

  • 0.4 mg (one capsule) daily, to be taken after meal at night
  • Dose may be increased after 2 to 4 weeks to 0.8 mg (two capsules) once daily
  • Capsule should be swallowed whole with a glass of water (about 150 ml)
  • Should not be crunched or chewed

Interaction

  • Concurrent administration with other alfa1-adrenoceptor antagonists could lead to hypotensive effects
  • No interactions with atenolol, enalapril or nifedipine
  • Cimetidine brings about a rise and frusemide a fall in plasma levels
  • Increase the elimination rate by Diclofenac and warfarin

Contraindications

  • Hypersensitivity to Tamsulosin hydrochloride
  • History of orthostatic hypotension
  • Severe hepatic insufficiency
  • Reduction in blood pressure can occur
  • Cautioned to avoid situations where injury could result
  • Examination to exclude other conditions which can cause the same symptoms
  • Digital rectal examination and determination of Prostate Specific Antigen (PSA) before treatment and at regular intervals afterwards

Side Effects

  • Dizziness
  • Abnormal ejaculation
  • Headache
  • Asthenia
  • Postural hypotension
  • Palpitations

Pregnancy & Lactation

  • Not recommended for use in pregnancy and lactation

Precautions & Warnings

  • Transient postural symptoms during orthostatic provocation testing after the first dose
  • Use in patients with micturition syncope is not advised
  • Effects on ability to drive and use machines
  • Dizziness can occur

Overdose Effects

  • No reported acute overdosage cases
  • Acute hypotension likely to occur after overdosage
  • Cardiovascular support should be given
  • Renal function monitoring and general supportive measures applied

Therapeutic Class

  • BPH/ Urinary retention/ Urinary incontinence

Storage Conditions

  • Store in a cool and dry place, below 30°C, protected from light

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