Enocef 1 gm/vial (IV Injection)
1 gm vial: ৳ 201.35
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Synovia pharma plc |
| Also available as |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
- 3rd generation broad-spectrum parenteral cephalosporin antibiotic
- Potent bactericidal activity
- Effective against Gram-positive and Gram-negative organisms
- Interferes with bacterial cell wall synthesis
- High stability in the presence of beta lactamases
- Long plasma elimination half-life of 6 to 9 hours
- Not metabolized in the body
- Excretion in urine and bile
- Highly protein bound (95%)
Dosage
- Adult dose: 1 to 2 gm by intravenous or intramuscular administration once a day or in equally divided doses twice a day
- Maximum adult dose: 4 gm/day
- Infants and Children dose: 50 to 75 mg/kg intravenous or intramuscular administration once a day or in equally divided doses twice a day
- Maximum pediatric dose: 2 gm/day
- Duration of therapy: 4 to 14 days or longer in complicated infections
Administration
- Preparation of Solutions for Intramuscular / Intravenous Injections
- Dissolving in 2 ml Lidocaine HCI 1% for Intramuscular Injection
- Reconstitution in Water for intravenous Injection
- Recommended administration over 2-4 minutes
- Patient tolerance test before treatment
- Potency maintenance for at least 6 hours at room temperature or 24 hours at 5°C
Interaction
No drug interactions reported
Contraindications
Not for patients with hypersensitivity to cephalosporin antibiotics
Side Effects
- Gastrointestinal effects like diarrhea, nausea, vomiting
- Cutaneous reactions including rash, pruritus, urticaria
- Hematologic reactions such as eosinophilia, thrombocytopenia, anemia
- Hepatic reactions like elevations of SGOT or SGPT
- CNS reactions including nervousness, confusion, sleep disturbances
- Rare occurrence of local phlebitis following intravenous administration
Pregnancy & Lactation
Safety in human pregnancy not established, caution in lactating mothers
Precautions & Warnings
- Potential for anaphylactic shock
- Monitor gallbladder condition
- Regular blood picture checks during prolonged treatment
- Avoid in neonates if premature or newborn (up to 28 days of age)
Use in Special Populations
Not for premature or newborn neonates
Overdose Effects
No specific antidote, symptomatic treatment for overdosage
Therapeutic Class
Third generation Cephalosporins
Storage Conditions
Store in a cool, dry place (below 30°C), away from light & moisture