Enocef 1 gm/vial (IV Injection)

1 gm vial: ৳ 201.35

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Synovia pharma plc
Also available as
Enocef 1 gm injection Enocef 250 mg injection Enocef 250 mg injection Enocef 500 mg injection Enocef 500 mg injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

  • 3rd generation broad-spectrum parenteral cephalosporin antibiotic
  • Potent bactericidal activity
  • Effective against Gram-positive and Gram-negative organisms
  • Interferes with bacterial cell wall synthesis
  • High stability in the presence of beta lactamases
  • Long plasma elimination half-life of 6 to 9 hours
  • Not metabolized in the body
  • Excretion in urine and bile
  • Highly protein bound (95%)

Dosage

  • Adult dose: 1 to 2 gm by intravenous or intramuscular administration once a day or in equally divided doses twice a day
  • Maximum adult dose: 4 gm/day
  • Infants and Children dose: 50 to 75 mg/kg intravenous or intramuscular administration once a day or in equally divided doses twice a day
  • Maximum pediatric dose: 2 gm/day
  • Duration of therapy: 4 to 14 days or longer in complicated infections

Administration

  • Preparation of Solutions for Intramuscular / Intravenous Injections
  • Dissolving in 2 ml Lidocaine HCI 1% for Intramuscular Injection
  • Reconstitution in Water for intravenous Injection
  • Recommended administration over 2-4 minutes
  • Patient tolerance test before treatment
  • Potency maintenance for at least 6 hours at room temperature or 24 hours at 5°C

Interaction

No drug interactions reported

Contraindications

Not for patients with hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastrointestinal effects like diarrhea, nausea, vomiting
  • Cutaneous reactions including rash, pruritus, urticaria
  • Hematologic reactions such as eosinophilia, thrombocytopenia, anemia
  • Hepatic reactions like elevations of SGOT or SGPT
  • CNS reactions including nervousness, confusion, sleep disturbances
  • Rare occurrence of local phlebitis following intravenous administration

Pregnancy & Lactation

Safety in human pregnancy not established, caution in lactating mothers

Precautions & Warnings

  • Potential for anaphylactic shock
  • Monitor gallbladder condition
  • Regular blood picture checks during prolonged treatment
  • Avoid in neonates if premature or newborn (up to 28 days of age)

Use in Special Populations

Not for premature or newborn neonates

Overdose Effects

No specific antidote, symptomatic treatment for overdosage

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Store in a cool, dry place (below 30°C), away from light & moisture

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