Urinide 1 mg (Tablet)

Unit Price: ৳ 10.05 (3 x 10: ৳ 301.50)
Strip Price: ৳ 100.50

Medicine Details

Category Details
Generic Bumetanide
Company Navana pharmaceuticals ltd
Also available as
Urinide 5 mg tablet

Indications

  • Treatment of edema associated with congestive heart failure
  • Treatment of edema associated with hepatic and renal disease
  • Treatment of edema associated with nephrotic syndrome

Pharmacology

  • Rapid onset and short duration of action
  • Diuretic potency equivalent to approximately 40 mg furosemide for 1 mg Bumetanide
  • Major site of action: ascending limb of the loop of Henle
  • Inhibits sodium and chloride reabsorption in the ascending limb
  • Potential additional action in the proximal tubule

Dosage & Administration

  • Oral dosage: 1 mg in the morning, repeat after 6-8 hours if necessary
  • Severe cases may require 5 mg daily, increased by 5 mg every 12-24 hours
  • Elderly dosage: 500 micrograms daily may be sufficient
  • IV Injection dosage: 1-2 mg, repeat after 20 minutes if necessary
  • IV Infusion dosage: 2-5 mg over 30-60 minutes
  • IM Injection dosage: 1 mg initially, then adjust according to response
  • Pediatric use safety and effectiveness not established

Interactions

  • Should not be administered concurrently with lithium
  • Concurrent therapy with probenecid is not recommended
  • Concurrent therapy with indomethacin is not recommended
  • May potentiate the effect of various antihypertensive drugs
  • No significant effect on digoxin blood levels
  • No effect on warfarin metabolism

Contraindications

  • Avoid in severe hypokalaemia
  • Avoid in severe hyponatraemia
  • Avoid in anuria
  • Avoid in comatose and precomatose states associated with liver cirrhosis
  • Avoid in renal failure

Side Effects

  • Muscle cramps
  • Dizziness
  • Hypotension
  • Headache
  • Nausea
  • ECG changes
  • Musculoskeletal pain
  • Abdominal pain
  • Renal failure
  • Thrombocytopenia

Pregnancy & Lactation

  • Pregnancy Category C
  • No adequate and well-controlled studies in pregnant women
  • Unknown excretion in human milk

Precautions & Warnings

  • Periodic measurement of serum potassium
  • Consider potassium supplements if necessary

Use in Special Populations

  • Safety and effectiveness in pediatric patients below the age of 18 not established

Overdose Effects

  • Acute profound water loss
  • Volume and electrolyte depletion
  • Dehydration
  • Reduction of blood volume
  • Circulatory collapse
  • Vascular thrombosis and embolism

Therapeutic Class

  • Loop diuretics

Storage Conditions

  • Keep below 30°C
  • Away from light & moisture
  • Keep out of reach of children

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