Peflacine 400 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Pefloxacin mesylate dihydrate |
| Company | Synovia pharma plc |
Title
Peflacine 400mg Tablet
Categories
- Medicine
- Antibacterial
- Fluoroquinolone
Description
Peflacine 400mg Tablet is indicated for the treatment of single infections or mixed infections caused by two or more susceptible microorganisms. It is also used for infections caused by organisms resistant to other antibiotics. It has a broad spectrum of activity with indications in gastrointestinal, urinary tract, respiratory tract, ear-nose-throat, bone-joint, skin-soft tissue, pelvic, abdominal-hepatobiliary infections, septicemia, bacteraemia, gonorrhea, endocarditis, and meningitis. Peflacine 400mg Tablet exerts its action by inhibiting the subunit-A of DNA gyrase (Topoisomerase II). It is administered orally in adult patients, with dosage readjustments required in severe hepatic insufficiency. Concomitant administration with antacids containing Aluminium and/or Magnesium Hydroxide gel should be avoided due to reduced absorption. Pefloxacin is contraindicated in patients with known hypersensitivity to Quinolone, children under 15 years, pregnant and lactating mothers, patients with inborn glucose-6-phosphate dehydrogenase deficiency, or a history of tendon lesion, tendonitis, or tendon rupture. It has been assigned to pregnancy category C by the FDA and requires precautions to avoid photosensitivity reactions, ultraviolet radiation exposure, and pain in the Achilles tendon. The medicine should be stored below 30°C temperature, away from light & moisture, and out of the reach of children.
Attributes
- Indications:
- Gastrointestinal infection
- Urinary tract infection
- Respiratory tract infection
- Ear, nose and throat infection
- Bone and joint infection
- Skin and soft tissue infection
- Pelvic infection
- Abdominal and hepatobiliary infection
- Septicemia
- Bacteraemia
- Gonorrhea
- Endocarditis
- Meningitis
- Pharmacology:
- Synthetic antibacterial agent
- Fluoroquinolone group
- Inhibits subunit-A of DNA gyrase
- Bactericidal
- Broad spectrum of activity
- Dosage & Administration:
- Adult with normal hepatic function: 400 mg tablet 12 hourly with meals
- An initial loading dose of 800 mg for effective blood concentration
- Hepatic insufficiency: Dosage readjustment required
- Renal insufficiency: Dosage need not be reduced
- Duration of Treatment: Usually 5 to 10 days
- Interaction:
- Reduced absorption with concomitant antacids containing Aluminium and/or Magnesium Hydroxide gel
- Contraindications:
- Known hypersensitivity to Quinolone
- Children under 15 years of age
- Pregnant and lactating mothers
- Inborn glucose-6-phosphate dehydrogenase deficiency
- History of tendon lesion, tendonitis, or tendon rupture
- Side Effects:
- Gastrointestinal disturbance
- Central nervous system disturbance
- Hypersensitivity reaction
- Myalgia and/or arthralgia
- Tendonitis
- Rupture of Achilles tendon
- Pregnancy & Lactation:
- Pregnancy category C by the FDA
- Precautions & Warnings:
- Risk of photosensitivity reaction
- Exposure to sunlight and ultraviolet radiation should be avoided
- Dosage readjustment required in severe hepatic insufficiency
- Possibility of pain in the Achilles tendon
- Therapeutic Class:
- 4-Quinolone preparations
- Storage Conditions:
- Below 30°C temperature
- Away from light & moisture
- Out of the reach of children