Pretor 50 mg (Capsule)
Medicine Details
| Category | Details |
|---|---|
| Generic | Pregabalin |
| Company | Synovia pharma plc |
| Also available as |
Indications
- Neuropathic pain associated with diabetic peripheral neuropathy (DPN)
- Postherpetic neuralgia (PHN)
- Adjunctive therapy for the treatment of partial-onset seizures in patients 1 month of age and older
- Fibromyalgia
- Neuropathic pain associated with spinal cord injury
Pharmacology
Pregabalin is a structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). It binds with high affinity to the alpha2-delta site in central nervous system tissues.
Dosage
- Maximum recommended dose of Pregabalin is 100 mg three times a day (300 mg/day) in patients with creatinine clearance of at least 60 ml/min
- Dosing should begin at 50 mg three times a day (150 mg/day)
- Pregabalin CR capsule dose should begin at 165 mg once daily and increase to 330 mg once daily within 1 week
Route of Administration
Oral route; can be taken with or without food; Pregabalin CR tablet should be administered after an evening meal.
Drug Interaction
- Unlikely to be involved in significant pharmacokinetic drug interactions
- Not applicable for food and others
Contraindications
Contraindicated in patients with known hypersensitivity to Pregabalin or any of its components.
Side Effects
- Dizziness
- Somnolence
- Dry mouth
- Edema
- Blurred vision
- Weight gain
- Difficulty with concentration/attention
- Increased weight
- Increased appetite
Pregnancy & Lactation
No adequate and well-controlled studies with pregabalin in pregnant women; small amounts of pregabalin have been detected in the milk of lactating women; breastfeeding is not recommended during treatment with pregabalin.
Precautions & Warnings
- Angioedema can occur and may be associated with life threatening respiratory compromise requiring emergency treatment
- Increase the risk of suicidal thoughts or behavior
- Respiratory depression may occur when used with concomitant CNS depressants or in the setting of underlying respiratory impairment
- May cause dizziness and impair the ability to drive or operate machinery
- Increased seizure frequency or other adverse reactions may occur if rapidly discontinued; should be withdrawn gradually over a minimum of 1 week
- May cause peripheral edema; caution should be exercised when coadministering with thiazolidinedione antidiabetic agents
Use in Special Populations
Safety and effectiveness have not been established in pediatric patients for various indications
Overdose Effects
Signs and symptoms include reduced consciousness, depression/anxiety, confusional state, agitation, restlessness, seizures, and heart block; no specific antidote; general supportive care of the patient is indicated
Therapeutic Class
- Adjunct anti-epileptic drugs
- Primary anti-epileptic drugs
Storage Conditions
Keep in a cool & dry place (below 30°C), protected from light & moisture; keep out of the reach of children
Chemical Structure
- Molecular Formula: C8H17NO2
- Chemical Structure Image URL: https://medex.com.bd/storage/res/g-res-919-pregabalin-chemical-structure-dKjKzfuVRrNkwNMBalNK.svg
Common Questions about Pretor 50 mg Capsule
- What is Pretor 50 mg Capsule?: An anticonvulsant considered to be the first-line of treatment for neurotic pain, shingles, seizures, and fibromyalgia
- How long do I need to use Pretor 50 mg Capsule before I see improvement in my condition?: To be taken till improvement is observed
- At what frequency do I need to use Pretor 50 mg Capsule?: As prescribed by the doctor
- Should I use Pretor 50 mg Capsule empty stomach, before food or after food?: After food in a prescribed dosage
- What are the instructions for the storage and disposal of Pretor 50 mg Capsule?: Keep in a cool dry place in its original packaging; keep away from children and pets
- Does Pretor 50 mg Capsule work in the same way for each disease?: Works differently for different diseases
- How long do I need to take Pretor 50 mg Capsule?: Duration depends on the health condition; consult the doctor before consumption
- Is it necessary to continue taking Pretor 50 mg Capsule even if I feel fine?: Yes, do not stop without consulting the doctor
- Can I take Diazepam and Pretor 50 mg Capsule together?: Yes, they can be used together
- Can the use of Pretor 50 mg Capsule cause weight gain?: May cause weight gain due to increased hunger; consult a dietician if concerns arise