Anacare 1 mg (Tablet)
Unit Price: ৳ 40.00 (2 x 14: ৳ 1,120.00)
Strip Price: ৳ 560.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Anastrozole |
| Company | Drug international ltd |
Indications
- Adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer
- First-line treatment of postmenopausal women with hormone receptor-positive or hormone receptor unknown locally advanced or metastatic breast cancer
- Second-line treatment of advanced breast cancer in postmenopausal women with disease progression following tamoxifen therapy
Pharmacology
- Non-steroidal aromatase inhibitor
- Suppression of estrogen biosynthesis
- Inhibition of the aromatase enzyme
Dosage & Administration
- One tablet 1 mg taken once a day
- Continued use for advanced breast cancer until tumor progression
- Unknown optimal duration for adjuvant treatment of early breast cancer in postmenopausal women
- No dose changes for patients with mild-to-moderate hepatic impairment
- No dose changes for patients with renal impairment
- Safety and efficacy not established in pediatric patients
- Pharmacokinetics not affected by age
Interaction
- Co-administration with tamoxifen reduces Anacare plasma concentration
- Estrogen-containing therapies should not be used
- Unlikely to affect other drugs through cytochrome P450 inhibition
Contraindications
- Contraindicated in pregnancy and premenopausal women
- Hypersensitivity to the drug or excipients
Side Effects
- Serious adverse reactions: skin reactions, allergic reactions, changes in liver function tests
- Common adverse reactions: hot flashes, asthenia, arthritis, pain, hypertension, depression, nausea and vomiting, rash, osteoporosis, fractures, back pain, insomnia, headache, bone pain, peripheral edema, cough, dyspnea, pharyngitis, lymphedema
Pregnancy & Lactation
- Pregnancy Category X
- Unknown if excreted in human milk
- Consideration of discontinuing nursing or drug, weighing the importance to the mother
Precautions & Warnings
- Increased incidence of ischemic cardiovascular events in women with pre-existing ischemic heart disease
- Mean decrease in bone mineral density compared to baseline
- More patients reported elevated serum cholesterol
Overdose Effects
- Clinical trials conducted up to 60 mg in single dose
- Well tolerated up to 10 mg daily in postmenopausal women with advanced breast cancer
- No specific antidote to overdosage, treatment must be symptomatic
Therapeutic Class
- Hormonal Chemotherapy
Storage Conditions
- Keep below 30°C temperature
- Away from light and moisture
- Keep out of the reach of children