Cyphos 1 gm/vial (IV Infusion)

1 gm vial: ৳ 600.00

Medicine Details

Category	Details
Generic	Cyclophosphamide
Company	Drug international ltd
Also available as	Cyphos 200 mg injection

Indications

Malignant lymphomas treatment
Hodgkin's disease treatment
Leukemias treatment
Multiple myeloma treatment
Neuroblastoma treatment
Adenocarcinoma of the ovary treatment
Carcinoma of the breast treatment
Mycosis fungoides treatment
Retinoblastoma treatment

Pharmacology

Liver biotransformation
Active alkylating metabolites
Interference with growth of malignant cells
Cross-linking of tumor cell DNA
High oral bioavailability (>75%)
Elimination half-life of 3 to 12 hours
Plasma protein binding

Dosage & Administration

Initial intravenous dosing of 40 to 50 mg/kg
Oral dosing range of 1 to 5 mg/kg/day
Leukocyte count as dosage guide
Dialyzable metabolites
Renal function impact on pharmacokinetics
Treatment duration for nephrotic syndrome

Interaction

Metabolism rate affected by phenobarbital
Potentiation of succinylcholine chloride effect
Anesthesia alert within 10 days of use

Contraindications

Severely depressed bone marrow function
Previous hypersensitivity

Side Effects

Nausea and vomiting
Alopecia
Leukopenia
Thrombocytopenia or anemia
Hemorrhagic ureteritis and renal tubular necrosis
Interstitial pneumonitis
Malaise and asthenia

Pregnancy & Lactation

Pregnancy Category D
Excretion in breast milk

Precautions & Warnings

Leukopenia
Thrombocytopenia
Tumor cell infiltration of bone marrow
Impaired hepatic function
Impaired renal function

Use in Special Populations

Pediatric use safety profile
Geriatric use data

Overdose Effects

Supportive measures
Appropriate treatment for concurrent effects

Therapeutic Class

Cytotoxic Chemotherapy

Storage Conditions

Temperature not exceeding 25°C
Protection from light and moisture
Avoid freezing

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