Cyphos 1 gm/vial (IV Infusion)
1 gm vial: ৳ 600.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cyclophosphamide |
| Company | Drug international ltd |
| Also available as |
Indications
- Malignant lymphomas treatment
- Hodgkin's disease treatment
- Leukemias treatment
- Multiple myeloma treatment
- Neuroblastoma treatment
- Adenocarcinoma of the ovary treatment
- Carcinoma of the breast treatment
- Mycosis fungoides treatment
- Retinoblastoma treatment
Pharmacology
- Liver biotransformation
- Active alkylating metabolites
- Interference with growth of malignant cells
- Cross-linking of tumor cell DNA
- High oral bioavailability (>75%)
- Elimination half-life of 3 to 12 hours
- Plasma protein binding
Dosage & Administration
- Initial intravenous dosing of 40 to 50 mg/kg
- Oral dosing range of 1 to 5 mg/kg/day
- Leukocyte count as dosage guide
- Dialyzable metabolites
- Renal function impact on pharmacokinetics
- Treatment duration for nephrotic syndrome
Interaction
- Metabolism rate affected by phenobarbital
- Potentiation of succinylcholine chloride effect
- Anesthesia alert within 10 days of use
Contraindications
- Severely depressed bone marrow function
- Previous hypersensitivity
Side Effects
- Nausea and vomiting
- Alopecia
- Leukopenia
- Thrombocytopenia or anemia
- Hemorrhagic ureteritis and renal tubular necrosis
- Interstitial pneumonitis
- Malaise and asthenia
Pregnancy & Lactation
- Pregnancy Category D
- Excretion in breast milk
Precautions & Warnings
- Leukopenia
- Thrombocytopenia
- Tumor cell infiltration of bone marrow
- Impaired hepatic function
- Impaired renal function
Use in Special Populations
- Pediatric use safety profile
- Geriatric use data
Overdose Effects
- Supportive measures
- Appropriate treatment for concurrent effects
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Temperature not exceeding 25°C
- Protection from light and moisture
- Avoid freezing