Foly 10 mg/ml (IM/IV Injection)
50 mg vial: ৳ 400.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Folinic acid |
| Company | Drug international ltd |
| Also available as |
Indications
- Neutralising the immediate toxic effects of folic acid antagonists
- Calcium folinate rescue- a treatment technique using calcium folinate in conjunction with folic acid antagonists
- The treatment of megaloblastic anaemias
Composition
- Calcium Folinate Hydrate BP 6.249 mg equivalent to Folinic Acid 5 mg
- Calcium Folinate Hydrate BP 18.746 mg equivalent to Folinic Acid 15 mg
Pharmacology
- Calcium Folinate Hydrate as a metabolite and active form of folic acid
- Involvement as a cofactor for 1-carbon transfer reactions
- Impairment of thymidylate synthesis in patients with folic acid deficiency
Dosage & Administration
- Commencement of calcium folinate rescue within 24 hours of methotrexate administration
- Dosage regimens varying depending upon the dose of methotrexate administered
- Recommended dose of Folinic Acid to counteract hematologic toxicity from folic acid antagonists
Interaction
- Counteract the antiepileptic effect of phenobarbitone, phenytoin and primidone
- Increase the frequency of seizures in susceptible patients with large amounts of folinates
- Caution required during concurrent administration with fluoropyrimidine
Contraindications
- Known hypersensitivity to calcium folinate or any other components
- Pernicious anemia or other megaloblastic anemia where vitamin B12 is deficient
- Rare hereditary problems of galactose intolerance, lapp lactase deficiency or glucose-galactose malabsorption
Side Effects
- Mucositis
- Stomatitis
- Leukopenia
- Diarrhea
Pregnancy & Lactation
- No adequate and well-controlled clinical studies conducted in pregnant women
- Use in pregnant women only if potential benefit justifies potential risk to the fetus
- Unknown excretion in human milk
Precautions & Warnings
- Use only under the direct supervision of a clinician experienced in the use of cancer chemotherapeutic agents
- Treatment of inadvertent overdosage should be administered as soon as possible
- Measures to ensure the prompt excretion of methotrexate are important as part of Calcium Folinate Rescue Therapy
Overdose Effects
- No reported sequelae in patients who have received significantly more calcium folinate than recommended dosage
- Excessive amounts may nullify the chemotherapeutic effect of folic acid antagonists
- No specific antidote to calcium folinate overdose
Therapeutic Class
- Supportive Care Therapy
Storage Conditions
- Do not store above 30°C
- Keep away from light and out of the reach of children