Getinib 250 mg (Tablet)
Unit Price: ৳ 250.00 (4 x 7: ৳ 7,000.00)
Strip Price: ৳ 1,750.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Gefitinib |
| Company | Drug international ltd |
Indications
- First-line treatment for metastatic non-small cell lung cancer
- Treatment for tumors with EGFR exon 19 deletions or exon 21 L858R substitution mutations
Pharmacology
- Reversibly inhibits kinase activity of EGFR
- Prevents autophosphorylation of tyrosine residues
- Inhibits EGFR-dependent proliferation
- Binds with higher affinity to specific EGFR mutations
- Inhibits IGF and PDGF-mediated signaling
Dosage & Administration
- Recommended dose: 250mg orally once daily
- Can be taken with or without food
- Tablets can be immersed in water for patients with difficulty swallowing
Interaction
- Interactions with CYP3A4 inducers and inhibitors
Contraindications
- Contraindicated in patients with hypersensitivity to Gefitinib or its components
Side Effects
- Common side effects include Interstitial Lung Disease, Hepatotoxicity, Gastrointestinal Perforation, Severe or Persistent Diarrhea, Ocular Disorders, Bullous and Exfoliative Skin Disorders
Pregnancy & Lactation
- No adequate and well-controlled studies in pregnant women
- Potential hazard to fetus or risk for loss of pregnancy
- Not known if excreted in human milk
- Recommendation to discontinue breastfeeding during treatment
Precautions & Warnings
- Prompt investigation for ILD with worsening respiratory symptoms
- Monitoring of liver function testing
- Withholding and discontinuation for severe adverse reactions like ILD, hepatotoxicity, gastrointestinal perforation, severe or persistent diarrhea, ocular disorders, and skin disorders
Use in Special Populations
- Safety and effectiveness not established in pediatric patients
- No clinical studies in patients with severe renal impairment
- Monitoring adverse reactions in patients with hepatic impairment
Therapeutic Class
- Targeted Cancer Therapy
Storage Conditions
- Store between 20-25°C
- Store in a cool and dry place away from sunlight
- Keep out of the reach of children