Daxotel 80 mg/vial (IV Infusion)

80 mg vial: ৳ 10,000.00

Medicine Details

Category Details
Generic Docetaxel trihydrate
Company Drug international ltd
Also available as
Daxotel 20 mg injection

Product Information

  • Daxotel Microtubule Inhibitor

Categories

  • Antineoplastic Agent
  • Cytotoxic Chemotherapy

Description

  • Docetaxel is an antineoplastic agent that disrupts the microtubular network in cells, inhibiting mitosis and cellular functions

Indications

  • Indicated for Breast Cancer (BC) as a single agent for locally advanced or metastatic BC after chemotherapy failure
  • Indicated for Non-small Cell Lung Cancer (NSCLC) as a single agent for locally advanced or metastatic NSCLC after platinum therapy failure
  • Indicated for Castration-Resistant Prostate Cancer (CRPC) with prednisone in metastatic CRPC
  • Indicated for Gastric Adenocarcinoma (GC) with cisplatin and fluorouracil for untreated, advanced GC including the gastroesophageal junction
  • Indicated for Squamous Cell Carcinoma of the Head and Neck (SCCHN) with cisplatin and fluorouracil for induction treatment of locally advanced SCCHN

Pharmacology

  • Acts by disrupting the microtubular network in cells
  • Promotes the assembly of tubulin into stable microtubules
  • Inhibits disassembly of microtubules
  • Binds to free tubulin, decreasing the critical intracellular concentration of tubulin

Dosage & Administration

  • Administer intravenously over 1 hr every 3 weeks
  • Dosage ranges for different indications
  • PVC equipment not recommended, use only a 21 gauge needle to withdraw docetaxel from the vial
  • Premedicate with oral corticosteroids
  • Adjust dose as needed

Interaction

  • CYP3A4 substrate, metabolism may be modified by concomitant administration of certain compounds

Contraindications

  • Neutrophil counts of <1500 cells/mm3
  • History of severe hypersensitivity reactions to docetaxel or drugs formulated with polysorbate 80

Side Effects

  • Common adverse reactions include infections, neutropenia, anemia, febrile neutropenia, hypersensitivity, thrombocytopenia, neuropathy, dysgeusia, dyspnea, constipation, anorexia, nail disorders, fluid retention, asthenia, pain, nausea, diarrhea, vomiting, mucositis, alopecia, skin reactions, myalgia
  • Incidence varies depending on the indication

Pregnancy & Lactation

  • Can cause fetal harm when administered to a pregnant woman
  • No information regarding presence in human milk or effects on breastfed child

Precautions & Warnings

  • Administered under supervision of a physician experienced in antineoplastic agents
  • Higher risk of severe adverse reactions in patients with hepatic impairment
  • Not to be given to patients with neutrophil counts of less than 1,500 cells/mm3
  • Fatal cases of enterocolitis reported, close monitoring required
  • Severe hypersensitivity reactions may occur, close monitoring required
  • Treatment related acute myeloid leukemia may occur

Overdose Effects

  • No known antidote for docetaxel overdose
  • Complications may include bone marrow suppression, peripheral neurotoxicity, mucositis
  • Patients should receive therapeutic G-CSF as soon as possible after discovery of overdose

Therapeutic Class

  • Cytotoxic Chemotherapy

Storage Conditions

  • Store between 2°C and 25°C, protected from light, freezing does not adversely affect the product

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