Letrozol 2.5 mg (Tablet)

Unit Price: ৳ 40.00 (2 x 14: ৳ 1,120.00)
Strip Price: ৳ 560.00

Medicine Details

Category Details
Generic Letrozole
Company Drug international ltd

Indications

  • Adjuvant treatment of postmenopausal women with hormone receptor positive early breast cancer
  • First-line treatment in postmenopausal women with hormone-dependent advanced breast cancer
  • Treatment of advanced breast cancer in women with postmenopausal status
  • Pre-operative therapy in postmenopausal women with hormone receptor positive breast cancer
  • Subsequent treatment after surgery should be in accordance with standard of care

Pharmacology

  • Mechanism of Action: Aromatase inhibition leading to estrogen biosynthesis reduction
  • Pharmacokinetics:
    • Absorption: Rapid and complete from gastrointestinal tract
    • Protein Binding: Approximately 60%
    • Metabolic Clearance: Slow clearance pathway

Dosage & Administration

  • Recommended Dose for Adult and Elderly Patients: 2.5 mg once daily
  • Duration of Treatment in Adjutant Setting: 5 years or until tumor relapse occurs
  • Duration of Treatment in Metastatic Disease: Until tumor progression is evident
  • Dosage Adjustment for Patients with Hepatic and/or Renal Impairment: Not required for renal impairment (creatinine clearance =10 mL/min)

Interaction

No clinically significant drug reactions

Contraindications

  • Hypersensitivity to letrozole or other aromatase inhibitors
  • Pregnancy and lactation
  • Severe hepatic dysfunction

Side Effects

  • Common:
    • Hot flushes
    • Increased level of cholesterol
    • Fatigue
    • Pain in bones and joints
    • Skin rash
  • Rare:
    • Nervous disorders
    • Memory problems
    • Insomnia
    • Eye disorders such as blurred vision

Pregnancy & Lactation

Not recommended in pregnant women and nursing mothers

Precautions & Warnings

  • Caution in breast cancer patients with moderate hepatic dysfunction
  • No dose adjustment for renal function impairment

Overdose Effects

No clinical experience of overdosage

Therapeutic Class

Hormonal Chemotherapy

Storage Conditions

Keep below 30°C temperature, away from light & moisture

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