Purinol 100 mg (Tablet)
Unit Price: ৳ 4.05 (5 x 10: ৳ 202.50)
Strip Price: ৳ 40.50
Medicine Details
| Category | Details |
|---|---|
| Generic | Allopurinol |
| Company | Drug international ltd |
| Also available as |
Indications
- Reduction of urate/uric acid formation
- Management of gouty arthritis
- Management of 2,8-DHA renal stones
- Management of calcium oxalate renal stones
Pharmacology
- Xanthine oxidase inhibitor
- Oral administration
- Reduction of uric acid production
- Plasma half-life of 1 to 2 hours
- Approximately 90% absorption from GI tract
Dosage & Administration
- Initial low dosage for reduced risk of adverse reactions
- Different recommended dosage schedules for mild, moderate, and severe conditions
- Specific dosages for children and elderly
- Dosage adjustments in renal impairment
Interaction
- Interaction with 6-mercaptopurine or azathioprine
- Prolonged activity of 6-mercaptopurine or azathioprine
- Increased plasma half-life of vidarabine
- Monitoring of theophylline levels
- Enhanced toxic effects with concomitant use of certain drugs
- Increased plasma concentration of ciclosporin
Contraindications
- Contra-indicated in patients with known hypersensitivity to allopurinol
Side Effects
- Rashes
- Gastrointestinal disorders
- Malaise
- Headache
- Vertigo
- Drowsiness
- Visual and test disturbances
- Hypertension
- Alopecia
- Hepatotoxicity
- Neuropathy
- Gynecomastia
- Blood disorders
Pregnancy & Lactation
- Inadequate evidence of safety in human pregnancy
- Use in pregnancy only when no safer alternative exists
- Lack of data on effects on breastfed baby
Precautions & Warnings
- Immediate withdrawal in case of skin rash or sensitivity
- Reduced doses in patients with hepatic or renal impairment
- Caution in patients under treatment for hypertension or cardiac insufficiency
Overdose Effects
- Reported ingestion of up to 22.5 g without adverse effect
- Symptoms including nausea, vomiting, diarrhea, and dizziness
- Hydration for facilitation of excretion
- Possibility of haemodialysis if necessary
Therapeutic Class
- Drugs used in Gout
Storage Conditions
- Keep below 30°C temperature
- Away from light and moisture
- Keep out of reach of children