Frusin 20 mg/2 ml (IM/IV Injection)

2 ml ampoule: ৳ 9.00 (2 x 5: ৳ 90.00)

Medicine Details

Category Details
Generic Furosemide
Company Opsonin pharma ltd
Also available as
Frusin 40 mg tablet Frusin 20 mg syrup

Indications

  • Fluid retention associated with chronic congestive cardiac failure
  • Fluid retention associated with acute congestive cardiac failure
  • Fluid retention associated with chronic renal failure
  • Maintenance of fluid excretion in acute renal failure
  • Fluid retention associated with nephrotic syndrome
  • Fluid retention associated with liver disease
  • Hypertension
  • Hypertensive crisis
  • Support of forced diuresis
  • Maintenance of fluid excretion in acute renal failure due to pregnancy or burns

Pharmacology

  • Monosulphonyl diuretic
  • Effective diuretic
  • Active in low glomerular filtration rate (GFR)
  • Distinctive action on renal tubular function
  • Affects peak diuresis
  • Prompts onset of action
  • Inhibition of sodium and chloride transport in the ascending limb of the loop of Henle
  • Independence of action from acid-base balance changes
  • Readily absorbed from the gastrointestinal tract
  • Considerable proportion bound to plasma proteins
  • Rapidly excreted in the urine

Dosage & Administration

  • Initial adult dose of 40 mg daily (reduced as required)
  • Daily doses of 80mg or higher may be required in some patients
  • Initial dose for children and elderly patients
  • Recommended dosage for hypertension
  • Maximum daily dose for different tablet strengths
  • Wide dosage range for Furosemide Liquid
  • Dosage for intramuscular, intravenous, and continuous intravenous infusion administration

Interaction

  • Marked fall in blood pressure when ACE inhibitors are added
  • Increased serum lithium levels when given concomitantly
  • Increased toxic effects of nephrotoxic antibiotics

Contraindications

  • Anuria
  • Electrolyte deficiency
  • Pre-comatose states associated with liver cirrhosis
  • Hypersensitivity to furosemide or sulphonamides

Side Effects

  • Disturbance in electrolytes and water balance
  • Potential for alkalosis
  • Possibility of uric acid retention
  • Risk for provoking hyperglycemia and glycosuria

Pregnancy & Lactation

  • Pregnancy category C
  • Caution in cardiogenic shock and the first trimester of pregnancy
  • Monitoring of blood pressure and pulse during rapid diuresis
  • Potential inhibition of lactation or passage into breast milk

Precautions & Warnings

  • Increased risk of acute retention in patients with prostatic hypertrophy or impairment of micturition
  • Special caution when ACE inhibitors are added to Frusin therapy
  • Increased risk with concomitant administration of nephrotoxic antibiotics
  • Adverse effects on concentration and reaction abilities

Overdose Effects

  • Clinical signs and symptoms
  • Management options and limitations

Therapeutic Class

  • Loop diuretics

Storage Conditions

  • Protection from light
  • Expiry date limitation
  • Keep out of the reach of children
  • Dispense only on the prescription of a registered physician

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