Maxfer 500 mg/10 ml (IV Injection or Infusion)

10 ml vial: ৳ 700.00

Medicine Details

Category Details
Generic Ferric carboxymaltose
Company Eskayef pharmaceuticals ltd
Also available as
Maxfer 1 gm injection

Indications

  • Treatment of iron deficiency anaemia in adult patients with intolerance to oral iron
  • Treatment of iron deficiency anaemia in adult patients with unsatisfactory response to oral iron
  • Treatment of iron deficiency anaemia in adult patients with non-dialysis dependent chronic kidney disease

Description

  • Colloidal iron (III) hydroxide in complex with Carboxymaltose

Dosage & Administration

  • Stepwise approach for determination and administration of individual iron need
  • Individual iron need based on body weight and haemoglobin level
  • Calculation and administration of maximum individual iron dose(s)
  • Post-iron repletion assessments by the clinician

Interaction

  • Formal drug interaction studies not performed

Contraindications

  • Hypersensitivity to the active substance or any of its excipients
  • Serious hypersensitivity to other parenteral iron products
  • Anaemia not attributed to iron deficiency
  • Evidence of iron overload or disturbances in the utilisation of iron

Side Effects

  • Infrequent and mild side effects
  • Nausea
  • Headache
  • Dizziness
  • Hypertension
  • Injection site reactions
  • Nausea
  • Hypophosphataemia
  • Hypersensitivit
  • Dysgeusia
  • Tachycardia
  • Hypotension
  • Flushing
  • Dyspnoea
  • Dyspepsia
  • Abdominal pain
  • Constipation
  • Diarrhea
  • Pruritus
  • Urticaria
  • Erythema
  • Rash
  • Myalgia
  • Back pain
  • Arthralgia
  • Muscle spasms
  • Pyrexia
  • Fatigue
  • Chest pain
  • Edema peripheral
  • Chills
  • Anaphylactoid reactions
  • Loss of consciousness
  • Anxiety
  • Phlebitis
  • Syncope
  • Presyncope
  • Bronchospasm
  • Flatulence
  • Angioedema
  • Pallor
  • Face edema
  • Rigors
  • Malaise
  • Influenza like illness

Pregnancy & Lactation

  • No adequate and well-controlled trials in pregnant women
  • Careful benefit/risk evaluation required before use during pregnancy
  • Unlikely risk to the breast-fed child

Precautions & Warnings

  • Serious hypersensitivity reactions reported
  • Monitoring for signs and symptoms of hypersensitivity
  • Administering only when immediate treatment for serious hypersensitivity reactions is available
  • Transient elevations in systolic blood pressure
  • Monitoring for signs and symptoms of hypertension
  • Laboratory test alterations in the 24 hours following administration
  • Laboratory assays may overestimate serum iron and transferrin bound iron

Use in Special Populations

  • Limit on the maximum daily injection dose for haemodialysis-dependent chronic kidney disease patients
  • Not recommended in children under 14 years

Overdose Effects

  • Accumulation of iron in storage sites potentially leading to hemosiderosis
  • Monitoring of iron parameters may assist in recognising iron accumulation
  • Consideration of iron chelator in case of iron accumulation

Therapeutic Class

  • Parenteral Iron Preparations

Storage Conditions

  • Store in a cool and dry place below 30°C
  • Keep away from light
  • Do not freeze
  • Keep out of the reach of children

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