Nabumet 500 mg (Tablet)

Indications

• Relief of signs and symptoms of osteoarthritis
• Relief of signs and symptoms of rheumatoid arthritis

Pharmacology

• Non-steroidal anti-inflammatory drug (NSAID)
• Exhibits anti-inflammatory properties
• Exhibits analgesic properties
• Exhibits antipyretic properties
• Mode of action not fully known
• Inhibits prostaglandin synthesis

Dosage & Administration

• Dosage forms: 500 mg & 750 mg tablets, 1000 mg tablets
• Oral administration
• Recommended starting dose: 1000 mg
• Maximum daily dose: 2000 mg
• Variation in doses for different conditions
• Caution in patients with renal insufficiency
• Not established for pediatric use

Interaction

• Potential interaction with ACE-inhibitors

Contraindications

• Hypersensitivity to nabumetone or its excipients
• History of asthma, urticaria, or allergic reactions to aspirin or NSAIDs
• Contraindicated for peri-operative pain in CABG surgery

Side Effects

• Gastrointestinal effects
• Central Nervous System effects
• Dermatologic effects
• Special Senses effects
• Miscellaneous effects

Pregnancy & Lactation

• Pregnancy Category C
• Use during pregnancy only if essential
• Not recommended during the third trimester
• Not recommended for nursing mothers

Precautions & Warnings

• Associated with renal papillary necrosis in animals
• Potential renal toxicity in certain conditions
• Increased risk in patients with impaired renal function, heart failure, liver dysfunction, or using diuretics
• Discontinuation may lead to recovery

Overdose Effects

• Symptoms of acute overdose
• Gastrointestinal complications
• Rare complications like hypertension, acute renal failure, and coma
• Management by supportive care
• No specific antidotes

Therapeutic Class

• Drugs for Osteoarthritis
• Drugs for Rheumatoid Arthritis

Storage Conditions

• Store in cool and dry place
• Keep away from light and moisture
• Keep out of reach of children

Chemical Structure

• Molecular Formula: C15H16O2

Common Questions about Nabumet 500 mg Tablet

• Used for relieving pain and inflammation
• Used for osteoarthritis and rheumatoid arthritis
• Quick Tips for usage and precautions

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