Macrosol (13.125 gm+350.7 mg+178.5 mg+46.6 mg)/25 ml (Oral Solution)
100 ml bottle: ৳ 160.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Polyethylene glycol 3350 electrolytes |
| Company | Popular pharmaceuticals ltd |
Indications
- Effective relief from constipation in adults and children over 12 years
- Treatment of chronic constipation
- Treatment of fecal impaction (refractory constipation with fecal loading)
- Relief from fecal impaction
Composition
- Polyethylene Glycol 3350: 13.125 gm in 25 ml concentrated oral solution
- Sodium Chloride: 350.7 mg in 25 ml concentrated oral solution
- Sodium Bicarbonate: 178.5 mg in 25 ml concentrated oral solution
- Potassium Chloride: 46.6 mg in 25 ml concentrated oral solution
- Polyethylene Glycol 3350: 13.125 gm in each sachet (powder for suspension)
- Sodium chloride: 350.7 mg in each sachet (powder for suspension)
- Sodium Bicarbonate: 178.5 mg in each sachet (powder for suspension)
- Potassium Chloride BP: 46.6 mg in each sachet (powder for suspension)
Pharmacology
- Osmotic action in the gut
- Laxative effect
- Increases stool volume
- Triggers colon motility
- Improved propulsive colonic transportation
- Facilitation of defecation
- Electrolyte exchange across the intestinal barrier
- Virtually unabsorbed from the gastrointestinal tract
Dosage & Administration
- Dose varies for constipation and fecal impaction
- Dilution instructions for oral solution
- Dosage adjustment for patients with renal insufficiency
Interaction
- Transient reduction in absorption of other medicinal products
- Possibility of decreased efficacy with some concomitantly administered medicinal products
Contraindications
- Intestinal perforation or obstruction
- Ileus
- Severe inflammatory conditions of the intestinal tract
- Toxic megacolon
- Hypersensitivity to the active substances
Side Effects
- Allergic reactions
- Electrolyte disturbances (hyperkalaemia, hypokalaemia)
- Abdominal pain
- Diarrhea
- Headache
- Peripheral edema
Pregnancy & Lactation
- No anticipated effects during pregnancy
- Safe for use during pregnancy
- Negligible systemic exposure to breastfed newborn/infant
- Safe for use during breastfeeding
Precautions & Warnings
- Dosage adjustments for patients with impaired cardiovascular function
- Monitoring for symptoms indicating fluid/electrolyte shifts
- Possible dependence with prolonged use
Overdose Effects
- Treatment for severe pain or distention
- Correction of electrolyte disturbances
Therapeutic Class
- Osmotic purgatives
Storage Conditions
- Store below 30°C
- Protect from light
- Do not refrigerate
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